Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital
Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital
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DOI：
10.1038/s41467-020-17318-x
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发表时间：
2020-07-08
影响因子：
16.6
通讯作者：
Dobano, Carlota
中科院分区：
文献类型：
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作者：
Garcia-Basteiro, Alberto L.;Moncunill, Gemma;Dobano, Carlota
卫生保健工作者（HCW）是从患者或其他HCW同事获得SARS-CoV-2感染的高危人群。本研究旨在估计来自西班牙一家大型医院的随机HCW样本中对SARS-CoV-2的血清阳性率。在2020年3月28日至4月9日招募的578名参与者中，54名（9.3%,95% CI: 7.1-12.0）针对SARS-CoV-2的IgM和/或IgG和/或IgA血清阳性。SARS-CoV-2感染的累积流行率（存在抗体或过去或当前rRT-PCR阳性）为11.2% （65/578,95% CI: 8.8-14.1）。在有过去或目前感染证据的人中，40.0%（26/65）以前未被诊断为COVID-19。在这里，我们报告了在西班牙COVID-19流行高峰期HCW中抗体的血清阳性率相对较低。有很大一部分过去或现在感染的HCW以前没有被诊断出患有COVID-19，这需要在医院环境中定期进行积极的rRT-PCR检测。卫生保健工作者是SARS-CoV-2感染的高危人群。在这里，作者测定了西班牙一家大型参考医院医护人员的SARS-CoV-2血清阳性率，发现SARS-CoV-2感染（存在抗体或过去或目前的rRT-PCR阳性）的累积流行率为11%。
Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. This study aims at estimating the seroprevalence against SARS-CoV-2 in a random sample of HCW from a large hospital in Spain. Of the 578 participants recruited from 28 March to 9 April 2020, 54 (9.3%, 95% CI: 7.1-12.0) were seropositive for IgM and/or IgG and/or IgA against SARS-CoV-2. The cumulative prevalence of SARS-CoV-2 infection (presence of antibodies or past or current positive rRT-PCR) was 11.2% (65/578, 95% CI: 8.8-14.1). Among those with evidence of past or current infection, 40.0% (26/65) had not been previously diagnosed with COVID-19. Here we report a relatively low seroprevalence of antibodies among HCW at the peak of the COVID-19 epidemic in Spain. A large proportion of HCW with past or present infection had not been previously diagnosed with COVID-19, which calls for active periodic rRT-PCR testing in hospital settings. Health care workers (HCW) are a high-risk population for SARS-CoV-2 infection. Here, the authors determine seroprevalence against SARS-CoV-2 in HCWs of a large Spanish reference hospital and find a cumulative prevalence of SARS-CoV-2 infection (presence of antibodies or past or current positive rRT-PCR) of 11%.