Modern cerebrospinal fluid analyses for the diagnosis of diffuse large B-cell lymphoma of the CNS.
Modern cerebrospinal fluid analyses for the diagnosis of diffuse large B-cell lymphoma of the CNS.
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DOI：
10.2217/cns.13.63
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发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Schroers, Roland
中科院分区：
文献类型：
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作者：
Baraniskin, Alexander;Schroers, Roland
中枢神经系统淋巴瘤是罕见的侵袭性非霍奇金淋巴瘤的变体，其可呈现不同的神经系统症状，并且通常在诊断上具有挑战性。原发性中枢神经系统淋巴瘤在中枢神经系统内发生，其特征是累及大脑、软脑膜、眼睛，在极少数情况下还累及脊髓。继发性CNS淋巴瘤的特征在于系统性淋巴瘤向CNS的扩展。脑脊液（CSF）的多模式调查包括一个重要组成部分的诊断工作的患者与可疑的中枢神经系统淋巴瘤。脑脊液细胞病理学检查仍然被认为是诊断软脑膜恶性疾病的“金标准”。然而，细胞病理学在检测软脑膜淋巴瘤累及方面的敏感性很低。现代技术，包括蛋白化学和免疫表型研究，流式细胞术，分子遗传学分析的CSF可能会增加敏感性和特异性，因此，促进CNS淋巴瘤的诊断。这篇综述给出了一个概述和讨论的CSF分析在CNS淋巴瘤的当前方面。
CNS lymphomas represent rare and aggressive variants of extranodal non-Hodgkin's lymphomas, which may present with diverse neurological symptoms and are often diagnostically challenging. Primary CNS lymphomas develop within the CNS and characteristically involve the brain, leptomeninges, eyes and, in rare cases, spinal cord. Secondary CNS lymphomas are characterized by expansion of systemic lymphomas to the CNS. Multimodal investigation of cerebrospinal fluid (CSF) comprises an important component of the diagnostic work-up for patients with suspected CNS lymphomas. Cytopathological examination of the CSF is still regarded as the 'gold standard' for the diagnosis of leptomeningeal malignant disease. However, cytopathology has only a low sensitivity in detecting leptomeningeal lymphoma involvement. Modern technologies including proteochemical and immunophenotypic studies by flow cytometry, and molecular genetic analyses of CSF may increase sensitivity and specificity, therefore, facilitating the diagnosis of CNS lymphomas. This review gives an overview and discussion of the current aspects of CSF analyses in CNS lymphomas.