Cerebral Microvascular Lesions on High-Resolution 7-Tesla MRI in Patients With Type 2 Diabetes
Cerebral Microvascular Lesions on High-Resolution 7-Tesla MRI in Patients With Type 2 Diabetes
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DOI：
10.2337/db14-0122
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发表时间：
2014-10-01
期刊：
影响因子：
7.7
通讯作者：
Biessels, Geert Jan
中科院分区：
文献类型：
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作者：
Brundel, Manon;Reijmer, Yael D.;Biessels, Geert Jan
脑小血管疾病，包括微血管病变，被认为在 2 型糖尿病 (T2DM) 相关认知缺陷的发展中发挥重要作用。通过超高场 MRI，现在可以在体内观察微血管病变（例如微梗塞和微出血）。在当前的研究中，48 名非痴呆老年 T2DM 患者（平均年龄 70.3 +/- 4.1 岁）和 49 名年龄、性别和教育程度匹配的对照受试者接受了 7-Tesla 脑部 MRI 扫描和详细的认知评估。分别通过液体衰减反转恢复以及 T1 加权和 T2* 加权图像评估皮质微梗塞和脑微出血的发生，比较各组之间的情况，并与认知表现相关。 38% 的对照受试者和 48% 的 T2DM 患者发现微梗塞。 41% 的对照受试者和 33% 的患者存在微出血（所有 P > 0.05）。微梗塞或微出血的存在和数量与认知能力无关。这项研究表明，超高场 MRI 上的微血管脑损伤在控制良好的 T2DM 患者中并不比对照受试者明显更常见。
Cerebral small vessel disease, including microvascular lesions, is considered to play an important role in the development of type 2 diabetes mellitus (T2DM)-associated cognitive deficits. With ultra-high field MRI, microvascular lesions (e.g., microinfarcts and microbleeds) can now be visualized in vivo. For the current study, 48 nondemented older individuals with T2DM (mean age 70.3 +/- 4.1 years) and 49 age-, sex-, and education-matched control subjects underwent a 7-Tesla brain MRI scan and a detailed cognitive assessment. The occurrence of cortical microinfarcts and cerebral microbleeds was assessed on fluid-attenuated inversion recovery and T1-weighted and T2*-weighted images, respectively, compared between the groups, and related to cognitive performance. Microinfarcts were found in 38% of control subjects and 48% of patients with T2DM. Microbleeds were present in 41% of control subjects and 33% of patients (all P > 0.05). The presence and number of microinfarcts or microbleeds were unrelated to cognitive performance. This study showed that microvascular brain lesions on ultra-high field MRI are not significantly more common in well-controlled patients with T2DM than in control subjects.