Scratching behavior in mice induced by the proteinase-activated receptor-2 agonist, SLIGRL-NH2
Scratching behavior in mice induced by the proteinase-activated receptor-2 agonist, SLIGRL-NH2
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DOI：
10.1016/j.ejphar.2005.11.012
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发表时间：
2006-01-20
影响因子：
5
通讯作者：
Collins, JG
中科院分区：
文献类型：
--
作者：
Shimada, SG;Shimada, KA;Collins, JG
我们研究了蛋白酶激活受体2（PAR 2）激动剂H-Ser-Leu-IIe-Gly-Arg-Leu-NiH 2（SLIGRL-NH 2）是否能诱导小鼠的抓挠行为。皮内注射SLIGRL-NH 2（10-50 μ g）诱发剂量依赖性抓挠。这种行为在5分钟附近达到峰值，并在30分钟内恢复到注射前水平。用组胺H-1受体拮抗剂吡拉明预处理动物，阻断组胺诱导的抓挠，但对SLIGRL抓挠的影响不大。我们的研究表明PAR 2介导组胺非依赖性瘙痒。(c)2005 Elsevier B. V.保留所有权利。
We examined whether the proteinase-activated receptor-2 (PAR2) agonist, H-Ser-Leu-IIe-Gly-Arg-Leu-NiH2 (SLIGRL-NH2), could induce scratching behavior in mice. Intradermal injections of SLIGRL-NH2 (10-50 mu g) evoked dose dependent scratching. This behavior peaked near 5 min and returned to preinjection levels within 30 min. Pretreatment of animals with a histamine H-1 receptor antagonist, pyrilamine, blocked histamine induced scratching, but it had little effect on SLIGRL scratching. Our study suggests that PAR2 mediates histamine independent itch. (c) 2005 Elsevier B.V. All rights reserved.