Brain-derived neurotropic factor polymorphisms, traumatic stress, mild traumatic brain injury, and combat exposure contribute to postdeployment traumatic stress
Brain-derived neurotropic factor polymorphisms, traumatic stress, mild traumatic brain injury, and combat exposure contribute to postdeployment traumatic stress
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DOI：
10.1002/brb3.392
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发表时间：
2016-01-01
影响因子：
3.1
通讯作者：
Iverson, Grant L.
中科院分区：
文献类型：
--
作者：
Dretsch, Michael N.;Williams, Kathy;Iverson, Grant L.
背景除了在战斗环境中部署时经历创伤性事件外，还有其他因素导致军人创伤后应激障碍（PTSD）的发展。本研究探讨了遗传，童年环境，先前的创伤，心理，认知和部署因素的发展部署后的创伤性应激反应的贡献。方法对458名战士中的231名战士进行了部署前和部署后的资料分析。部署后评估在返回美国后30天内进行，包括一系列心理健康，病史和人口统计学问卷;神经认知测试;以及D2多巴胺受体（DRD 2），载脂蛋白E（APOE）和脑源性神经营养因子（BDNF）基因的血清。结果创伤后应激筛查阳性的士兵在抑郁（d=1.91）、焦虑（d= 1.61）、睡眠质量差（d=0.92）、脑震荡后症状（d=2.21）、饮酒（d=0.63）、创伤性生活事件（d=0.42）和战斗暴露（d=0.91）方面得分显著高于对照组。BDNF Val 66 Met基因型与维持轻度创伤性脑损伤（mTBI）和创伤性应激筛查阳性的风险显著相关。部署前创伤应激、更大的战斗暴露和部署时持续的mTBI，以及BDNF Met/Met基因型解释了部署后PTSD评分的22%的方差（R-2=0.22，P
Background In addition to experiencing traumatic events while deployed in a combat environment, there are other factors that contribute to the development of posttraumatic stress disorder (PTSD) in military service members. This study explored the contribution of genetics, childhood environment, prior trauma, psychological, cognitive, and deployment factors to the development of traumatic stress following deployment. Methods Both pre- and postdeployment data on 231 of 458 soldiers were analyzed. Postdeployment assessments occurred within 30days from returning stateside and included a battery of psychological health, medical history, and demographic questionnaires; neurocognitive tests; and blood serum for the D2 dopamine receptor (DRD2), apolipoprotein E (APOE), and brain-derived neurotropic factor (BDNF) genes. Results Soldiers who screened positive for traumatic stress at postdeployment had significantly higher scores in depression (d=1.91), anxiety (d=1.61), poor sleep quality (d=0.92), postconcussion symptoms (d=2.21), alcohol use (d=0.63), traumatic life events (d=0.42), and combat exposure (d=0.91). BDNF Val66 Met genotype was significantly associated with risk for sustaining a mild traumatic brain injury (mTBI) and screening positive for traumatic stress. Predeployment traumatic stress, greater combat exposure and sustaining an mTBI while deployed, and the BDNF Met/Met genotype accounted for 22% of the variance of postdeployment PTSD scores (R-2=0.22, P