Inhalable spray-dried formulation of D-LAK antimicrobial peptides targeting tuberculosis
Inhalable spray-dried formulation of D-LAK antimicrobial peptides targeting tuberculosis
复制标题
DOI：
10.1016/j.ijpharm.2015.07.001
复制
发表时间：
2015-08-01
影响因子：
5.8
通讯作者：
Lam, Jenny K. W.
中科院分区：
文献类型：
--
作者：
Kwok, Philip Chi Lip;Grabarek, Adam;Lam, Jenny K. W.
Tuberculosis (TB) is a global disease that is becoming more difficult to treat due to the emergence of multidrug resistant (MDR) Mycobacterium tuberculosis. Inhalable antimicrobial peptides (AMPs) are potentially useful alternative anti-TB agents because they can overcome resistance against classical antibiotics, reduce systemic adverse effects, and achieve local targeting. The aims of the current study were to produce inhalable dry powders containing D-enantiomeric AMPs (D-LAK120-HP13 and D-LAK120-A) and evaluate their solid state properties, aerosol performance, and structural conformation. These two peptides were spray dried with mannitol as a bulking agent at three mass ratios (peptide: mannitol 1:99, 1:49, and 1:24) from aqueous solutions. The resultant particles were spherical, with those containing D-LAK120-HP13 being more corrugated than those with D-LAK120-A. The median volumetric diameter of the particles was approximately 3 mu m. The residual water content of all powders were
