Tumour dormancy: findings and hypotheses from clinical research on breast cancer
Tumour dormancy: findings and hypotheses from clinical research on breast cancer
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DOI：
10.1006/scbi.2001.0385
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发表时间：
2001-08-01
影响因子：
14.5
通讯作者：
Demicheli, R
中科院分区：
文献类型：
--
作者：
Demicheli, R
乳腺癌转移性发展通常被认为是由肿瘤种植的持续肿瘤生长导致的，直到记录到临床复发。然而，持续增长模型的推论，无法解释临床发现有关局部复发，以及首次治疗失败的时间分布和接受乳房切除术的患者的死亡率。肿瘤休眠假说被认为提供了一个更合理的描述乳腺癌的自然史，而原发性肿瘤切除被认为是一个潜在的干扰因素转移的发展。一个新的模型的自然历史的可手术的乳腺癌，将肿瘤休眠和启动信号从手术微转移生长的建议。
Breast cancer metastatic development is commonly considered as resulting from continuous tumour growth from tumour seeding until clinical recurrence is documented. Continuous growth model inferences, however, fail to explain clinical findings concerning local recurrences, as well as the time-distribution of first treatment failure and mortality for patients undergoing mastectomy. The tumour dormancy hypothesis is considered to provide a more reasonable description of the natural history of breast cancer, while primary tumour removal is believed to be a potential perturbing factor for metastasis development. A new model of the natural history of operable breast cancer, incorporating tumour dormancy and starting signals from surgery for micrometastatic growth is proposed.