Current advances in research and clinical applications of PLGA-based nanotechnology.

Current advances in research and clinical applications of PLGA-based nanotechnology.
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DOI:
10.1586/erm.09.15
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发表时间:
2009-05
影响因子:
5.1
通讯作者:
Chen C
Chen C
中科院分区:
医学3区
文献类型:
--
作者:
Lü JM;Wang X;Marin-Muller C;Wang H;Lin PH;Yao Q;Chen C

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共聚物聚(乳酸 - 羟基乙酸)(PLGA)纳米技术已经发展了多年,并已被美国食品药品监督管理局批准用于药物递送、诊断以及临床和基础科学研究的其他应用,包括心血管疾病、癌症、疫苗和组织工程。本文介绍了在这些医学相关应用中应用基于PLGA的纳米技术和工具的最新成果。它侧重于PLGA制剂和装置可能的作用机制、诊断和治疗效果。这些最新信息将有益于对PLGA纳米技术的开发和应用感兴趣的新手和资深研究科学家以及临床医生,将其作为许多疾病的新治疗和诊断策略。
Co-polymer poly(lactic-co-glycolic acid) (PLGA) nanotechnology has been developed for many years and has been approved by the US FDA for the use of drug delivery, diagnostics and other applications of clinical and basic science research, including cardiovascular disease, cancer, vaccine and tissue engineering. This article presents the more recent successes of applying PLGA-based nanotechnologies and tools in these medicine-related applications. It focuses on the possible mechanisms, diagnosis and treatment effects of PLGA preparations and devices. This updated information will benefit to both new and established research scientists and clinical physicians who are interested in the development and application of PLGA nanotechnology as new therapeutic and diagnostic strategies for many diseases.
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