Modification of motor cortical excitability by an acetylcholinesterase inhibitor
Modification of motor cortical excitability by an acetylcholinesterase inhibitor
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DOI：
10.1007/s00221-005-2326-6
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发表时间：
2005-07-01
影响因子：
2
通讯作者：
Ziemann, U
中科院分区：
文献类型：
--
作者：
Korchounov, A;Ilic, TV;Ziemann, U
乙酰胆碱能有效调节新皮质神经元和神经网络的兴奋性。本研究采用局灶经颅磁刺激（TMS）对8名健康受试者进行单次口服40mg乙酰胆碱酯酶抑制剂他克林对运动皮质兴奋性的影响。结果发现，他克林降低短时间期皮质内抑制，提高短时间期皮质内促进作用。运动阈值、运动诱发电位振幅、皮质沉默期（CSP）持续时间以及脊髓和神经肌肉兴奋性的测量保持不变。作用在2-6小时达到顶峰，24小时后完全逆转。所有的作用都可以通过激活突触前毒毒碱M2受体来减少运动皮质gaba能抑制性神经传递来解释，但其他更复杂的机制也可能起作用并进行了讨论。研究结果预测，乙酰胆碱有可能促进人类运动皮层的可塑性和学习能力。
Acetylcholine powerfully modulates the excitability of neocortical neurones and networks. This study applied focal transcranial magnetic stimulation (TMS) to eight healthy subjects to test the effects of a single oral dose of 40 mg tacrine, an acetylcholinesterase inhibitor, on motor cortical excitability. It was found that tacrine decreased short-interval intracortical inhibition, and increased intracortical facilitation and short-interval intracortical facilitation. Motor thresholds, motor evoked potential amplitude, cortical silent period (CSP) duration, and measures of spinal and neuromuscular excitability remained unchanged. The effects peaked at 2-6 h and fully reversed after 24 h. All effects can be explained by a reduction of motor cortical GABAergic inhibitory neurotransmission via activation of presynaptic muscarinic M2 receptors, but other more complex mechanisms may also have contributed and are discussed. The findings predict that acetylcholine has the potential to promote plasticity and learning in human motor cortex.