Binding of immunoglobulin G antibodies in Guillain-Barre syndrome sera to a mixture of GM1 and a phospholipid: Possible clinical implications
Binding of immunoglobulin G antibodies in Guillain-Barre syndrome sera to a mixture of GM1 and a phospholipid: Possible clinical implications
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DOI：
10.1002/mus.10307
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发表时间：
2003-03-01
期刊：
影响因子：
3.4
通讯作者：
Kanazawa, I
中科院分区：
文献类型：
--
作者：
Kusunoki, S;Morita, D;Kanazawa, I
抗GM 1免疫球蛋白G（IgG）抗体经常存在于格林-巴利综合征（GBS）患者的血清中。之前有报道称，一名患有神经病的患者的免疫球蛋白M（IgM）M蛋白与磷脂酸（PA）和神经节苷脂形成的构象表位结合，这促使我们研究GBS血清中IgG抗体与GM的结合1和PA的混合物（GM 1/PA）。在121例GBS患者中，32例有抗GM 1 IgG抗体。所有32只小鼠均具有抗GM 1/PA的抗体活性。32例患者中有25例（78%）对GM 1/PA的活性大于对GM 1单独的活性。12例无抗GM 1 IgG抗体的患者有抗GM 1/PA的IgG抗体活性。GBS患者均未检测到单独的PA IgG抗体。相反，两种兔抗GM 1抗血清对单独的GM 1比对GM 1/PA具有更大的活性。与GM 1和磷脂的混合物的结合活性大于单独对GM 1的IgG抗体可能在GBS的发病机制中具有重要作用，并具有诊断意义。
Anti-GM1 immunoglobulin G (IgG) antibodies are frequently present in sera from patients with Guillain-Barre syndrome (GBS). A previous report on a patient who had a neuropathy with immunoglobulin M (IgM) M-protein binding to a conformational epitope formed by phosphatidic acid (PA) and gangliosides prompted us to investigate the binding of IgG antibodies in GBS sera to a mixture of GM1 and PA (GM1/PA). Of 121 GBS patients, 32 had anti-GM1 IgG antibodies. All 32 also had antibody activity against GM1/PA. Twenty-five (78%) of 32 patients had greater activity against GM1/PA than against GM1 alone. Twelve patients who had no anti-GM1 IgG antibodies had IgG antibody activity against GM1/PA. No GBS patient had IgG antibody against PA alone. In contrast, two rabbit anti-GM1 antisera had greater activity against GM1 alone than against GM1/PA. IgG antibody with greater binding activity against a mixture of GM1 and a phospholipid than against GM1 alone may have an important role in the pathogenesis of GBS and has implications for diagnosis.