Long-term sequelae of hippocampal lesions in patients with transient global amnesia: A multiparametric MRI study
Long-term sequelae of hippocampal lesions in patients with transient global amnesia: A multiparametric MRI study
复制标题
短暂性全面遗忘症患者海马病变的长期后遗症：多参数 MRI 研究
DOI：
10.1002/jmri.25844
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发表时间：
2018
影响因子：
4.4
通讯作者：
Zhang JX
中科院分区：
文献类型：
--
作者：
Wang Xiaochuan;Jiang Haibo;Gao Zhongming;Zhang Ran;Zhang Jiaxing;Wei Wenping;Lin Jianzhong;Lin JZ;Zhang JX
BACKGROUNDMRI signal diffusion‐weighted imaging (DWI) hyperintensity in the hippocampus in patients with transient global amnesia (TGA) are resolved within several days after the onset of TGA.PURPOSETo use multiparametric MRI to unravel the sequelae of TGA.STUDY TYPEA prospective longitudinal study.POPULATIONEight TGA patients.FIELD STRENGTH/SEQUENCEA 3.0T Siemens Tim Trio MRI scanner with T1‐weighted MPRAGE, diffusion‐weighted echo planar imaging, and multiecho gradient‐recalled echo sequences.ASSESSMENTBrain MRI scanned within 72 hours, 2 weeks, and 3 months after onset of TGA, respectively. T1image hippocampus was first segmented into 12 subregions using FreeSurfer and registered to DWI to locate DWI lesion. Then a T1image with segmented hippocampus was registered to its corresponding apparent diffusion coefficient (ADC) map, fractional anisotropy (FA) map, and quantitative susceptibility map, respectively. Finally, the volume, water diffusion and anisotropy, and magnetic susceptibility of DWI lesion were analyzed.STATISTICAL TESTSA paired samplest‐test was performed to detect measurement differences between three tests. Pearson correlation was used to assess the correlations between all measurements.RESULTSHyperintensity was detected in the head, body, and caudate of CA1 and hippocampal tail. No significant changes existed in CA1/unit volume across the three timepoint measurements (all,P> 0.480). In Test 1, ratio ADC (DWI lesion / adjacent healthy, rADC) and ratio FA (rFA) decreased below, while ratio susceptibility increased above 1.0. In Test 2, all the episodes normalized around 1.0. In Test 3, rADC remained normalization, but rFA decreased and ratio susceptibility increased again. In Test 1 and Test 3 (vs. Test 2), decreased FA values were accompanied with lower axial diffusivity and/or higher radial diffusivity (all,P< 0.001). Moreover, rFA significantly correlated with ratio susceptibility in Test 3 (r= −0.665,P= 0.039).DATA CONCLUSIONMicrostructural sequelae in hippocampus were demonstrated, which indicates that ischemic lesions may be associated with TGA.Level of Evidence: 2Technical Efficacy: Stage 3J. Magn. Reson. Imaging 2018;47:1350–1358.
