Type 2 diabetes as a "coronary heart disease equivalent" -: An 18-year prospective population-based study in Finnish subjects
Type 2 diabetes as a "coronary heart disease equivalent" -: An 18-year prospective population-based study in Finnish subjects
复制标题
DOI：
10.2337/diacare.28.12.2901
复制
发表时间：
2005-12-01
期刊：
影响因子：
16.2
通讯作者：
Laakso, M
中科院分区：
文献类型：
--
作者：
Juutilainen, A;Lehto, S;Laakso, M
目的 - 本研究的目的是调查以下假设：没有先兆冠心病证据的糖尿病受试者的冠心病 (CHD) 死亡率与既往有心肌梗塞或任何先兆冠心病证据的非糖尿病受试者的冠心病 (CHD) 死亡率相同。 研究设计和方法 - 在一项为期 18 年的随访期间，芬兰一项基于人口的研究记录了心血管疾病 (CVD) 和先心病 (CHD) 死亡，该研究纳入了 1,373 名非糖尿病和冠心病患者。 1,059 名糖尿病受试者。 结果 - 调整后的多变量 Cox 风险模型表明，与既往有心肌梗塞的非糖尿病受试者相比，没有既往心肌梗塞的糖尿病受试者的 CHD 死亡风险的风险比 (HR) 为 0.9 (95% CI 0.6-1.5)。男性相应的 HR 为 0.9 (0.5-1.4)，女性相应的 HR 为 1.9 (0.6 - 6.1)。与先前有 CHD 证据的非糖尿病受试者相比，没有任何先心病证据（心肌梗塞或缺血性心电图 [ECG] 变化或心绞痛）的糖尿病受试者，先心病死亡的 HR 为 1.9 (1.4-2.6)（男性 1.5 [1.0-2.2]；女性 3.5 [1.8-6.8]）。 CVD 和总死亡率的结果与 CHD 死亡率的结果非常相似。 结论 - 既往患有糖尿病但未患过心肌梗塞的患者和既往患有心肌梗塞但未患糖尿病的患者。表明男性和女性冠心病死亡的风险相似。然而，先前没有任何冠心病证据（心肌梗死或心绞痛或缺血性心电图变化）的糖尿病表明，在非糖尿病受试者中，尤其是女性，其风险比先前有冠心病证据的风险更高。
OBJECTIVE - The purpose of this study was to investigate the hypothesis that coronary heart disease (CHD) mortality in diabetic subjects without prior evidence of CHD is equal, to that in nondiabetic subjects with prior myocardial infarction or any prior evidence of CHD.RESEARCH DESIGN AND METHODS - During an 18-year follow-up total, cardiovascular disease (CVD) and CHD deaths were registered in a Finnish population-based Study of 1,373 nondiabetic and 1,059 diabetic subjects.RESULTS - Adjusted multivariate Cox hazard models indicated that diabetic subjects without prior myocardial infarction, compared with nondiabetic subjects with prior myocardial infarction, had a hazard ratio (HR) of 0.9 (95% CI 0.6-1.5) for the risk of CHD death. The corresponding HR was 0.9 (0.5-1.4) in men and 1.9 (0.6 - 6.1) in women. Diabetic subjects without any prior evidence of CHD (myocardial infarction or ischemic electrocardiogram [ECG] changes or angina pectoris), compared with nondiabetic subjects with prior evidence of CHD, had an HR of 1.9 (1.4-2.6) for CHD death (men 1.5 [1.0-2.2]; women 3.5 [1.8-6.8]). The results for CVD and total mortality were quite similar to those for CHD mortality.CONCLUSIONS - Diabetes without prior myocardial infarction and prior myocardial infarction without diabetes. indicate similar risk for CHD death in men and women. However, diabetes without any prior evidence of CHD (myocardial infarction or angina pectoris or ischemic ECG changes) indicates a higher risk than prior evidence of CHD in nondiabetic subjects, especially in women.