Amelioration of atherosclerosis by tanshinone IIA in hyperlipidemic rabbits through attenuation of oxidative stress
Amelioration of atherosclerosis by tanshinone IIA in hyperlipidemic rabbits through attenuation of oxidative stress
复制标题
DOI：
10.1016/j.ejphar.2011.10.040
复制
发表时间：
2012-01-15
影响因子：
5
通讯作者：
Liu, Peiqing
中科院分区：
文献类型：
--
作者：
Chen, Wenying;Tang, Futian;Liu, Peiqing
氧化应激在动脉粥样硬化形成中起着至关重要的作用，这增加了使用抗氧化剂来改善动脉粥样硬化的可能性。本研究旨在观察丹参酮IIA（TSIIA）对高脂血症家兔动脉粥样硬化的影响。高脂饲料喂养90天后，他们开发了严重的动脉粥样硬化病变的形态学和生化，并表现出显着升高的血脂，丙二醛（MDA）和氧化低密度脂蛋白（oxLDL）水平。口服TSIIA（3-30 mg/kg）可显著抑制动脉粥样硬化病变的形成。在TSIIA治疗的家兔，有一个显着的降低血清和主动脉脂质过氧化物产物的含量，代表MDA和oxLDL，而增强的超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）的活性进行了观察。然而. TSIIA对血脂谱没有影响。提示TSIIA通过降低oxLDL的生成，提高SOD和GPx的活性，减轻氧化应激，从而改善动脉粥样硬化。(C)2011 Elsevier B. V.保留所有权利。
Oxidative stress plays a crucial role in atherogenesis, which raises the possibility of using antioxidants to ameliorate atherosclerosis. In the present study, we aim to determine the effects of tanshinone IIA (TSIIA) on atherosclerosis in hyperlipidemic rabbits. After feeding the rabbits on a high-lipid diet for 90 days, they developed severe atherosclerotic lesions both morphologically and biochemically and exhibited significantly elevated serum lipid, malondialdehyde (MDA) and oxidized low density lipoprotein (oxLDL) levels. Oral administration of TSIIA (3-30 mg/kg) greatly inhibited the formation of atherosclerotic lesions. In TSIIA-treated rabbits, there was a marked reduction in serum and aortic lipid peroxide product content, represented by MDA and oxLDL, whereas enhanced activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were observed. However. TSIIA had no effect on serum lipid profiles. These results suggest that TSIIA attenuates oxidative stress by decreasing oxLDL production and enhancing activities of SOD and GPx, which might be contributed to the amelioration of atherosclerosis. (C) 2011 Elsevier B.V. All rights reserved.