Relationship of hepcidin with parasitemia and anemia among patients with uncomplicated Plasmodium falciparum malaria in Ghana
Relationship of hepcidin with parasitemia and anemia among patients with uncomplicated Plasmodium falciparum malaria in Ghana
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DOI：
10.4269/ajtmh.2007.77.623
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发表时间：
2007-10-01
影响因子：
3.3
通讯作者：
Semba, Richard D.
中科院分区：
文献类型：
--
作者：
Howard, Caitlin T.;McKakpo, Uri S.;Semba, Richard D.
疟疾性贫血的发病机制尚不完全清楚。铁调素是一种最近发现的肽激素，是铁代谢的主要调节剂，被认为在慢性炎症性贫血中发挥着核心作用。该研究的具体目的是确定加纳 199 名接受恶性疟原虫疟疾评估的患者的尿铁调素、血红蛋白和寄生虫血症之间的关系。使用表面增强激光解吸/电离飞行时间质谱法对尿铁调素进行半定量评估。尿铁调素（强度/毫摩尔肌酐）与 86 名儿童（β = 0.086，标准误差 [SE] = 0.035，P < 0.017）、31 名孕妇（β = 0.218，SE = 0.085，P < 0.016）和 82 名成人（β = 0.184，SE = 0.043，P < 0.0001）。尿铁调素与血红蛋白或贫血没有显着相关性。在加纳的急性恶性疟原虫疟疾患者中，尿铁调素与寄生虫血症的相关性比血红蛋白或贫血的相关性更强。
The pathogenesis of malarial anemia is incompletely understood. Hepcidin, a recently discovered peptide hormone, is a major regulator of iron metabolism and is thought to play a central role in the anemia of chronic inflammation. The specific aim of the study was to characterize the association between urinary hepcidin, hemoglobin, and parasitemia in 199 patients presenting for evaluation of Plasmodium falciparum malaria in Ghana. Urinary hepcidin was semi-quantitatively assessed using surf ace-enhanced laser desorption/ionization time-of-flight mass spectrometry. Urinary hepcidin (intensity/mmol creatinine) was associated with log parasitemia in 86 children (beta = 0.086, standard error [SE] = 0.035, P < 0.017), 31 pregnant women (beta = 0.218, SE = 0.085, P < 0.016), and 82 adults (beta = 0.184, SE = 0.043, P < 0.0001). Urinary hepcidin was not significantly associated with hemoglobin or anemia. Urinary hepcidin is more strongly associated with parasitemia than hemoglobin or anemia among patients with acute P. falciparum malaria in Ghana.