Receptor-mediated tobacco toxicity:: Alterations of the NF-κB expression and activity downstream of α7 nicotinic receptor in oral keratinocytes
Receptor-mediated tobacco toxicity:: Alterations of the NF-κB expression and activity downstream of α7 nicotinic receptor in oral keratinocytes
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DOI：
10.1016/j.lfs.2007.01.013
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发表时间：
2007-05-30
期刊：
影响因子：
6.1
通讯作者：
Grando, Sergei A.
中科院分区：
文献类型：
--
作者：
Arredondo, Juan;Chernyavsky, Alexander I.;Grando, Sergei A.
为了深入了解烟草制品在口腔中的尼古丁受体依赖性发病机制，我们研究了正常人口腔角质形成细胞（KC）暴露于环境烟草烟雾（ETS）与等效浓度的纯尼古丁24小时的影响。核因子-κ B（NF-κ B）在mRNA和蛋白水平均呈倍数增加，这可能是显著的（p
To gain a mechanistic insight into nicotinic receptor-dependent morbidity of tobacco products in the oral cavity, we studied effects of exposures of normal human oral keratinocytes (KCs) for 24 h to environmental tobacco smoke (ETS) vs. equivalent concentration of pure nicotine. The exposed KCs showed a multifold increase of nuclear factor-kappa B (NF-kappa B) at the mRNA and protein levels, which could be significantly (p