Increased neuronal excitability during depolarization‐induced suppression of inhibition in rat hippocampus.
Increased neuronal excitability during depolarization‐induced suppression of inhibition in rat hippocampus.
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DOI：
10.1113/jphysiol.1996.sp021577
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发表时间：
1996-08
期刊：
影响因子：
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通讯作者：
J. Wagner;B. Alger
中科院分区：
文献类型：
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作者：
J. Wagner;B. Alger
1.去极化诱导的抑制抑制（DSI）是CNS中γ-氨基丁酸（GABAA）介导（以下称为“GABA能”）反应的可塑性形式。我们对CA 1锥体神经元进行了全细胞记录，以研究DSI对海马切片制备中兴奋性突触传递的影响。2.电压钳位兴奋性突触后电流（EPSC）的显著增强发生在时间重叠的抑制性突触后电流的DSI期间。在移液器溶液中高水平的钙螯合剂或荷包牡丹碱的浴应用下，EPSC增强被阻断，这表明它是由DSI引起的，并且DSI过程选择性地影响GABA能而不是谷氨酸能的传递。3.在电流钳下的DSI期间，突触诱发的动作电位放电的概率增加。DSI也可以影响其他兴奋现象。
1. Depolarization‐induced suppression of inhibition (DSI) is a form of plasticity of gamma‐amino‐butyric acid (GABAA)‐mediated (henceforth ‘GABAergic’) responses in the CNS. We made whole‐cell recordings from CA1 pyramidal neurons to investigate the effects of DSI on excitatory synaptic transmission in the hippocampal slice preparation. 2. Significant enhancement of the voltage‐clamped excitatory postsynaptic current (EPSC) occurs during DSI of the temporally overlapping inhibitory postsynaptic current. With high levels of calcium chelators in the pipette solution, or bath application of bicuculline, EPSC enhancement is blocked, suggesting that it results from DSI and that the DSI process selectively affects GABAergic, but not glutamatergic, transmission. 3. The probability of synaptically evoked action potential firing is increased during DSI under current clamp. DSI could influence other excitatory phenomena as well.