Primary Hepatic Burkitt’s Lymphoma with Chronic Hepatitis C
Primary Hepatic Burkitt’s Lymphoma with Chronic Hepatitis C
复制标题
原发性肝伯基特淋巴瘤伴慢性丙型肝炎
作者：
J. Kuroda;A. Omoto;H. Fujiki;K. Okugawa;H. Tamai;H. Yamagishi;Yutaka Kobayashi;T. Yoshikawa
肝脏是恶性淋巴瘤的罕见原发部位，原发性肝淋巴瘤占结外淋巴瘤的0.4%。我们报告一个罕见的75岁日本男性原发性肝伯基特淋巴瘤病例，根据修订的欧美淋巴瘤分类和新的世界卫生组织分类。由于Burkitt淋巴瘤的诊断不仅需要组织学表现，还需要免疫学特征，因此之前的7例原发性肝脏Burkitt淋巴瘤未采用这些标准进行全面评估。据我们所知，这是第一例原发性肝脏伯基特淋巴瘤，在组织学、免疫学和细胞遗传学分析上具有典型特征。他有几十年的慢性丙型肝炎病史，随后出现肝硬化。从我们的文献回顾和我们的病例来看，丙型肝炎病毒感染与原发性肝伯基特淋巴瘤发展之间的关系仍然不清楚。
The liver is an uncommon primary site for malignant lymphoma, and primary hepatic lymphoma has been found to make up 0.4% of all extranodal lymphomas. We report a rare case of a 75-year-old Japanese male with primary hepatic Burkitt’s lymphoma, according to both the revised European-American Lymphoma classification and the new World Health Organization classification. As not only histological findings but also immunological features are deemed essential in the diagnosis of Burkitt’s lymphoma, the previous 7 cases of primary hepatic Burkitt’s lymphoma were not fully evaluated, using these criteria. As far as we know, this is the first case of primary hepatic Burkitt’s lymphoma with typical features on histological, immunological and cytogenetical analysis. He had a history of chronic hepatitis C over several decades with subsequent liver cirrhosis. From our review of the literature and our case, the relationship between hepatitis C virus infection and the development of primary hepatic Burkitt’s lymphoma remains obscure.