Contact inhibition (of proliferation) redux
Contact inhibition (of proliferation) redux
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DOI：
10.1016/j.ceb.2012.06.009
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发表时间：
2012-10-01
影响因子：
7.5
通讯作者：
Yap, Alpha S.
中科院分区：
文献类型：
--
作者：
McClatchey, Andrea I.;Yap, Alpha S.
人们早就认识到，许多细胞的增殖受到密度的抑制，这种现象通常归因于细胞间的接触。这种现象的基本性质是在20世纪60年代确立的，同时也发现这种密度依赖性在转化细胞中也消失了。接触性增殖抑制（CIP）的机制基础揭示得较慢。在这里，我们讨论了最近在阐明细胞-细胞粘附分子作为CIP受体的作用以及表征介导粘附依赖性增殖抑制的细胞内信号通路方面的进展。
It has long been appreciated that proliferation of many cells is inhibited by density, a phenomenon that is often attributed to cell-cell contact. The basic properties of this phenomenon were established in the 1960s, along with the observation that such density-dependence was also lost in transformed cells. The mechanistic basis of contact inhibition of proliferation (CIP) has been slower to reveal itself. Here we discuss recent progress in elucidating the roles that cell-cell adhesion molecules play as receptors for CIP and in characterising the intracellular signaling pathways that mediate adhesion-dependent proliferative inhibition.