Chicoric acid ameliorate inflammation and oxidative stress in Lipopolysaccharide and d-galactosamine induced acute liver injury
Chicoric acid ameliorate inflammation and oxidative stress in Lipopolysaccharide and d-galactosamine induced acute liver injury
复制标题
菊苣酸可改善脂多糖和d-半乳糖胺诱导的急性肝损伤中的炎症和氧化应激
DOI：
10.1111/jcmm.14935
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发表时间：
2020-03-01
影响因子：
5.3
通讯作者：
Liu, Guowen
中科院分区：
文献类型：
--
作者：
Li, Zheng;Feng, Haihua;Liu, Guowen
菊苣酸是天然植物多酚类化合物，具有多种生物活性。急性肝损伤是由多种刺激因素引起的，病死率高。本实验观察了菊苣酸对脂多糖（LPS）和D-氨基半乳糖（d-GalN）诱导的急性肝损伤的保护作用。结果表明，CA能降低LPS/d-GalN诱导的小鼠血清谷草转氨酶（AST）和丙氨酸转氨酶（ALT），降低LPS/d-GalN诱导的小鼠死亡率。CA可以抑制有丝分裂原活化蛋白激酶（MAPKs）和核因子-kappa B（NF-kappa B），从而减轻炎症。同时，结果表明，CA可以激活核因子-红细胞2相关因子2（Nrf 2）途径，增加AMP激活蛋白激酶（AMPK）的水平。经CA处理后，自噬基因蛋白水平明显提高。实验结果表明，CA对肝损伤具有保护作用，其机制可能与激活AMPK和自噬有关。
Chicoric acid is polyphenol of natural plant and has a variety of bioactivity. Caused by various kinds of stimulating factors, acute liver injury has high fatality rate. The effect of chicoric acid in acute liver injury induced by Lipopolysaccharide (LPS) and d-galactosamine (d-GalN) was investigated in this study. The results showed that CA decreased the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum and reduced the mortality induced by LPS/d-GalN. CA can restrain mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-kappa B) to alleviate inflammation. Meanwhile, the results indicated CA can active nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway with increasing the level of AMP-activated protein kinase (AMPK). And with the treatment of CA, protein levels of autophagy genes were obvious improved. The results of experiments indicate that CA has protective effect in liver injury, and the activation of AMPK and autophagy may make sense.