MITOTIC AND WOUND-HEALING ACTIVITIES OF THE CORNEAL EPITHELIUM - EFFECT OF SENSORY DENERVATION
MITOTIC AND WOUND-HEALING ACTIVITIES OF THE CORNEAL EPITHELIUM - EFFECT OF SENSORY DENERVATION
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DOI：
10.1001/archopht.1954.00920050048005
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发表时间：
1954-01-01
期刊：
影响因子：
--
通讯作者：
FRIEDENWALD, JS
中科院分区：
文献类型：
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作者：
SIGELMAN, S;FRIEDENWALD, JS
描述了一种透热凝固程序，通过该程序，大鼠三叉神经的眼分支可被严重损伤。手术成功后，手术侧的眨眼反射完全丧失。一个暴发和严重形式的神经麻痹性角膜炎的结果。这种病变的一些特点进行了说明。角膜炎可以通过关闭眼睑来预防。因此，这是一种暴露性角膜炎。暴露性角膜炎是否仅由不眨眼决定，或因泪液分泌减少而加重，尚未确定。在通过眼睑闭合保护免于暴露的去神经角膜中，有丝分裂率降低约20%，角膜上皮的伤口愈合活动正常。电离辐射对有丝分裂抑制的敏感性没有改变。在角膜基质、内皮或上皮中未观察到组织学异常。
A diathermy coagulation procedure is described by which the ophthalmic branch of the trigeminal nerve in rats can be severely damaged. After successful operations there is complete loss of the blinking reflex on the operated side. A fulminating and severe form of neuroparalytic keratitis results. Some of the characteristics of this lesion are described. The keratitis can be prevented by closure of the eyelids. It is, therefore, a form of exposure keratitis. Whether the exposure keratitis is determined solely by absence of blinking or is aggravated by diminished lacrimal secretion was not determined. In the denervated cornea protected from exposure by lid closure, the mitotic rate was diminished approximately 20% and the wound healing activities by the corneal epithelium were normal. Sensitivity to mitotic inhibition by ionizing radiation was not altered. No histologic abnormalities were noted in the corneal stroma, endothelium, or epithelium.