Wherever I may roam: Protein and membrane trafficking in P. falciparum-infected red blood cells
Wherever I may roam: Protein and membrane trafficking in P. falciparum-infected red blood cells
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DOI：
10.1016/j.molbiopara.2012.09.007
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发表时间：
2012-12-01
影响因子：
1.5
通讯作者：
Przyborski, Jude M.
中科院分区：
文献类型：
--
作者：
Deponte, Marcel;Hoppe, Heinrich C.;Przyborski, Jude M.
除了作为人类病原体的巨大重要性之外，近年来的研究揭示了一个事实，即疟疾寄生虫恶性疟原虫是研究蛋白质运输的有趣的真核模型系统。研究寄生虫细胞生物学经常揭示非典型细胞生物学特征的过度表现，这可能是由于寄生虫需要在不寻常的生物生态位中生存。疟疾寄生虫具有不常见的细胞隔室，蛋白质运输必须指向这些隔室，包括分泌细胞器如棒状体和微丝，称为消化泡的溶酶体样隔室和复杂的（四个膜结合的）质体，顶质体。此外，寄生虫必须提供蛋白质的细胞外区室和结构，包括寄生虫空泡，寄生虫空泡膜，毛雷尔的裂缝和细胞质和质膜的宿主细胞，成熟的人红细胞。虽然这些不寻常的目的地是由其他类型的细胞拥有，只有疟原虫含有它们都在一个cell.In这里，我们审查已知的蛋白质和膜运输在恶性疟原虫感染的细胞，突出这些过程的新功能。越来越多的证据表明，这种寄生虫在蛋白质运输方面是一个真实的“诡计箱”。也许，这些技巧可以通过利用它们作为新的治疗靶点来对抗寄生虫。(C)2012爱思唯尔有限公司版权所有。
Quite aside from its immense importance as a human pathogen, studies in recent years have brought to light the fact that the malaria parasite Plasmodium falciparum is an interesting eukaryotic model system to study protein trafficking. Studying parasite cell biology often reveals an overrepresentation of atypical cell biological features, possibly driven by the parasites' need to survive in an unusual biological niche. Malaria parasites possess uncommon cellular compartments to which protein traffic must be directed, including secretory organelles such as rhoptries and micronemes, a lysosome-like compartment referred to as the digestive vacuole and a complex (four membrane-bound) plastid, the apicoplast. In addition, the parasite must provide proteins to extracellular compartments and structures including the parasitophorous vacuole, the parasitophorous vacuolar membrane, the Maurer's clefts and both cytosol and plasma membrane of the host cell, the mature human red blood cell. Although some of these unusual destinations are possessed by other cell types, only Plasmodium parasites contain them all within one cell.Here we review what is known about protein and membrane transport in the P. falciparum-infected cell, highlighting novel features of these processes. A growing body of evidence suggests that this parasite is a real "box of tricks" with regards to protein traffic. Possibly, these tricks may be turned against the parasite by exploiting them as novel therapeutic targets. (C) 2012 Elsevier B.V. All rights reserved.