Effects of magnesium sulphate on amplitude‐integrated continuous EEG in asphyxiated term neonates
Effects of magnesium sulphate on amplitude‐integrated continuous EEG in asphyxiated term neonates
复制标题
硫酸镁对窒息足月新生儿振幅积分连续脑电图的影响
DOI：
10.1111/j.1651-2227.2002.tb00102.x
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
L. Vries
中科院分区：
文献类型：
--
作者：
F. Groenendaal;C. Rademaker;M. Toet;L. Vries
在这项研究中，我们假设在窒息的足月新生儿中使用硫酸镁可能会导致振幅综合脑电图（aEEG）背景模式的逐渐改善，aEEG是缺氧缺血性脑损伤的早期标志。在一项双盲、随机、对照的试点研究中，22名窒息的足月新生儿接受硫酸镁治疗，使血清Mg2+水平达到2.5 mmol/L。硫酸镁对aEEG模式没有直接影响。在12小时时，8名镁治疗的新生儿中有6名的aEEG比3小时时的aEEG更低，14名安慰剂治疗的新生儿中有3名（Mg2+ vs安慰剂：p < 0.05, Mann - Whitney）。在12至24小时之间，aEEG未见进一步的显著变化。8名镁治疗的新生儿中有4名结局不利，14名安慰剂治疗的新生儿中有8名结局不利。
In this study it is hypothesized that magnesium sulphate in asphyxiated full‐term neonates could lead to a gradual improvement in background pattern of the amplitude integrated EEG (aEEG), an early marker of hypoxic‐ischaemic brain injury. In a double‐blind, randomized, controlled pilot study of 22 asphyxiated full‐term neonates 8 received magnesium sulphate, reaching serum Mg2+ levels of 2.5 mmol/L. Magnesium sulphate had no immediate effect on aEEG‐patterns. At 12 h of age, aEEG was more depressed compared with aEEG at 3 h in 6 of the 8 magnesium‐treated neonates, and in 3 of the 14 placebo‐treated neonates (Mg2+ vs placebo: p < 0.05, Mann‐Whitney). No further significant changes in aEEG were seen between 12 and 24 h. Outcome was unfavourable in 4 of the 8 magnesium‐treated neonates, and in 8 of the 14 placebo‐treated neonates.