Serum interleukin-18 and soluble tumour necrosis factor receptor 2 are associated with disease severity in patients with paracoccidioidomycosis
Serum interleukin-18 and soluble tumour necrosis factor receptor 2 are associated with disease severity in patients with paracoccidioidomycosis
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DOI：
10.1111/j.1365-2249.2006.03308.x
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发表时间：
2007-03-01
影响因子：
4.6
通讯作者：
Blotta, M. H. S. L.
中科院分区：
文献类型：
--
作者：
Corvino, C. L.;Mamoni, R. L.;Blotta, M. H. S. L.
白细胞介素（IL）-18是IL-1超家族的促炎细胞因子，其在先天性和获得性免疫应答中表现出广泛的功能效应，并且已经在几种慢性炎症和自身免疫性疾病中发现高水平。IL-18的过度表达可能促进感染的早期消退或可能促进有害的过度免疫应答。本研究的目的是测定IL-18和其他炎性介质[IL-12、可溶性细胞间粘附分子1（sICAM-1）、可溶性肿瘤坏死因子受体1（TNF-RI）、sTNF-RII、CXC趋化因子配体9（CXCL 9），基线时和抗真菌治疗后，幼年型（JF）和成年型（AF）副球孢子菌病（PCM）患者血清中的CXCL 10]，以及健康对照组（C），并评估其与疾病严重程度的可能关系。PCM JF组IL-18和sTNF-RII水平显著高于AF组和对照组。在sICAM-1方面，JF和AF患者之间没有观察到差异，但均呈现高于对照组的水平。PCM患者的sTNF-RI水平高于对照组，AF患者的sTNF-RI浓度显著高于JF患者。此外，IL-12和趋化因子CXCL 9和CXCL 10在患者中也高于对照组。JF患者IL-18水平与sICAM-1（r = 0.62，P < 0.0001）、sTNF-RI（r = 0.63，P < 0.0001）、sTNF-RII（r = 0.51，P = 0.02）及临床严重程度显著相关。结果表明血清IL-18和sTNF-Rs水平作为PCM严重程度的参数的价值，并可能支持它们在疾病发病机制中的可能作用。
Interleukin (IL)-18 is a proinflammatory cytokine of the IL-1 superfamily that exhibits broad functional effects in innate and acquired immune responses and which has been found in high levels in several chronic inflammatory and autoimmune diseases. Over-expression of IL-18 may promote early resolution of infection or could promote a detrimental exaggerated immune response. The aim of this study was to determine serum levels of IL-18 and other inflammatory mediators [IL-12, soluble intercellular adhesion molecule 1 (sICAM-1), soluble tumour necrosis factor receptor 1 (TNF-RI), sTNF-RII, CXC chemokine ligand 9 (CXCL9), CXCL10] at baseline and after anti-fungal therapy in serum from patients with juvenile (JF) and adult (AF) forms of paracoccidioidomycosis (PCM), as well as in healthy controls (C), and to assess their possible relationships to the severity of disease. IL-18 and sTNF-RII levels in patients with the JF of PCM were significantly higher than those in the AF and controls. In relation to sICAM-1, no difference was observed between JF and AF patients but both presented higher levels than controls. sTNF-RI levels were higher in patients with PCM than in controls, and significantly higher concentrations were detected in AF patients compared to JF patients. Moreover, IL-12 and chemokines CXCL9 and CXCL10 were also higher in patients than in controls. In JF patients IL-18 levels correlated significantly with sICAM-1 (r = 0.62, P < 0.0001), sTNF-RI (r = 0.63, P < 0.0001), sTNF-RII (r = 0.51, P = 0.02), as well as with clinical severity. The results suggest the value of serum IL-18 and sTNF-Rs levels as a parameter of PCM severity and may support a possible role for them in the pathogenesis of the disease.