Endogenous sex hormones and prostate cancer: A collaborative analysis of 18 prospective studies
Endogenous sex hormones and prostate cancer: A collaborative analysis of 18 prospective studies
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DOI：
10.1093/jnci/djm323
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发表时间：
2008-02-06
期刊：
影响因子：
--
通讯作者：
Key, Timothy J.
中科院分区：
文献类型：
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作者：
Roddam, Andrew W.;Allen, Naomi E.;Key, Timothy J.
背景血清中的性激素被假设会影响前列腺癌的风险。我们进行了合作分析现有的全球流行病学数据，以检查这些协会在一个统一的方式，并提供更精确的估计risk.Methods数据的血清性激素浓度从18个前瞻性研究，其中包括3886例男性前列腺癌和6438例对照组合并的内源性激素和前列腺癌协作组。采用条件Logistic回归分析，根据研究、招募时年龄和招募年份分层，估计血清激素浓度的五分之一前列腺癌的相对危险度（RR）。所有统计检验均为双侧。结果前列腺癌的风险和血清睾酮浓度，计算游离睾酮，双氢睾酮，硫酸脱氢表雄酮，雄烯二酮，雄甾烷葡糖苷酸，雌二醇，或计算游离雌二醇之间没有发现关联。血清性激素结合球蛋白浓度与前列腺癌风险呈中度负相关（最高与最低五分之一的RR = 0.86，95%置信区间= 0.75至0.98; P趋势= 0.01）。有没有统计学证据的异质性研究之间，调整潜在的混杂因素的风险estimate.Conclusions差异不大，在这一全球性的内源性激素和前列腺癌的风险数据的合作分析，血清性激素浓度与前列腺癌的风险。
Background Sex hormones in serum have been hypothesized to influence the risk of prostate cancer. We performed a collaborative analysis of the existing worldwide epidemiologic data to examine these associations in a uniform manner and to provide more precise estimates of risks.Methods Data on serum concentrations of sex hormones from 18 prospective studies that included 3886 men with incident prostate cancer and 6438 control subjects were pooled by the Endogenous Hormones and Prostate Cancer Collaborative Group. Relative risks (RRs) of prostate cancer by fifths of serum hormone concentration were estimated by use of conditional logistic regression with stratification by study, age at recruitment, and year of recruitment. All statistical tests were two-sided.Results No associations were found between the risk of prostate cancer and serum concentrations of testosterone, calculated free testosterone, dihydrotestosterone, dehydroepiandrosterone sulfate, androstenedione, androstanediol glucuronide, estradiol, or calculated free estradiol. The serum concentration of sex hormone-binding globulin was modestly inversely associated with prostate cancer risk (RR in the highest vs lowest fifth = 0.86, 95% confidence interval = 0.75 to 0.98; P-trend = .01). There was no statistical evidence of heterogeneity among studies, and adjustment for potential confounders made little difference to the risk estimates.Conclusions In this collaborative analysis of the worldwide data on endogenous hormones and prostate cancer risk, serum concentrations of sex hormones were not associated with the risk of prostate cancer.