Prostaglandin on cutaneous vasculature.
Prostaglandin on cutaneous vasculature.
复制标题
前列腺素对皮肤血管的影响。
DOI：
--
复制
发表时间：
1968
影响因子：
6.5
通讯作者：
Lennart Juhlin
中科院分区：
文献类型：
--
作者：
Lawrence M. Solomon;M Barry Kirschenbaum;Lennart Juhlin
本文研究了前列腺素E_1对16只豚鼠、6只兔、8名正常人和20例各种皮肤病患者皮肤血管的影响。PGE1在豚鼠和人皮肤中注射后被发现是一种有效的血管扩张剂。不能通过完整的表皮吸收。人体皮肤中的PGE1会导致长达10小时的红斑。红斑可被去甲肾上腺素和肾上腺素阻断，但不受麻醉剂的影响。在特应性皮炎患者中，PGE1似乎有血管扩张作用，而其他药物几乎没有或有矛盾的作用。PGF2对兔、豚鼠皮肤无明显影响。
The effect of PGE1 was studied on the cutaneous vasculature of 16 guinea pigs 6 rabbits 8 healthy human subjects and 20 patients with various dermatoses. PGE1 was found to be a potent vasodilator after injection in guinea pig and human skin. It was not absorbed through intact epidermis. PGE1 in human skin results in prolonged erythema for up to 10 hours. The erythema is blocked by norepinephrine and epinephrine but is unaffected by anesthetics. In patients with atopic dermatitis PGE1 appears to have a vasodilatory effect in contrast to other pharmacological agents which have little or paradoxical effect. PGF2 had no effect on rabbit and guinea pig skin.