A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B
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DOI：
10.1038/ng.660
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发表时间：
2010-10-01
期刊：
影响因子：
30.8
通讯作者：
Kadowaki, Takashi
中科院分区：
文献类型：
--
作者：
Yamauchi, Toshimasa;Hara, Kazuo;Kadowaki, Takashi
我们在日本人群中使用459，359个SNP进行了一项2型糖尿病（T2 D）的全基因组关联研究，研究设计分为三个阶段（第1阶段，4，470例病例和3，071例对照;第2阶段，2，886例病例和3，087例对照;第3阶段，3，622例病例和2，356例对照）。我们发现3号染色体上的UBE 2 E2和15号染色体上的C2CD 4A-C2CD 4 B在全基因组显著水平上存在新的关联（UBE 2 E2中的rs7612463，组合P = 2.27 x 10（-9）; C2CD 4A-C2CD 4 B中的rs7172432，组合P = 3.66 x 10（-9））。这两个位点与T2 D的关联在其他东亚人群中也得到了复制。在欧洲人群中，C2CD 4A-C2CD 4 B基因座与T2 D显著相关，所有人群的综合分析得出P = 8.78 x 10（-14），而UBE 2 E2基因座与T2 D无关联。总之，我们在UBE 2 E2和C2CD 4A-C2CD 4 B上发现了两个与T2 D易感性相关的新基因座。
We conducted a genome-wide association study of type 2 diabetes (T2D) using 459,359 SNPs in a Japanese population with a three-stage study design (stage 1, 4,470 cases and 3,071 controls; stage 2, 2,886 cases and 3,087 controls; stage 3, 3,622 cases and 2,356 controls). We identified new associations in UBE2E2 on chromosome 3 and in C2CD4A-C2CD4B on chromosome 15 at genome-wide significant levels (rs7612463 in UBE2E2, combined P = 2.27 x 10(-9); rs7172432 in C2CD4A-C2CD4B, combined P = 3.66 x 10(-9)). The association of these two loci with T2D was replicated in other east Asian populations. In the European populations, the C2CD4A-C2CD4B locus was significantly associated with T2D, and a combined analysis of all populations gave P = 8.78 x 10(-14), whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D.