A SOLUBLE RECEPTOR FOR INTERLEUKIN-1-BETA ENCODED BY VACCINIA VIRUS - A NOVEL MECHANISM OF VIRUS MODULATION OF THE HOST RESPONSE TO INFECTION
A SOLUBLE RECEPTOR FOR INTERLEUKIN-1-BETA ENCODED BY VACCINIA VIRUS - A NOVEL MECHANISM OF VIRUS MODULATION OF THE HOST RESPONSE TO INFECTION
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DOI：
10.1016/0092-8674(92)90274-g
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发表时间：
1992-10-02
期刊：
影响因子：
64.5
通讯作者：
SMITH, GL
中科院分区：
文献类型：
--
作者：
ALCAMI, A;SMITH, GL
痘苗病毒基因 B15R 编码丰富的分泌性糖蛋白，其功能相当于可溶性白细胞介素 1 (IL-1) 受体。这种 IL-1 受体具有新颖的特异性，因为与细胞对应物相比，它仅结合 IL-1β，而不结合 IL-1α 或天然竞争性 IL-1 受体拮抗剂。痘苗 IL-1β 受体在杆状病毒系统中表达时被分泌，并竞争性抑制 IL-1β 与 T 细胞上天然受体的结合。痘苗病毒中 B15R 的缺失加速了鼻内感染小鼠疾病和死亡症状的出现，表明痘苗病毒对 IL-1β 的阻断可以减弱对感染的全身急性期反应并调节疾病的严重程度。 IL-1β 结合活性存在于其他正痘病毒中。
Vaccinia virus gene B15R is shown to encode an abundant, secretory glycoprotein that functions as a soluble interleukin-1 (IL-1) receptor. This IL-1 receptor has novel specificity since, in contrast with cellular counterparts, it binds only IL-1beta and not IL-1alpha or the natural competitor IL-1 receptor antagonist. The vaccinia IL-1beta receptor is secreted when expressed in a baculovirus system and competitively inhibited binding of IL-1beta to the natural receptor on T cells. Deletion of B15R from vaccinia virus accelerated the appearance of symptoms of illness and mortality in intranasally infected mice, suggesting that the blockade of IL-1beta by vaccinia virus can diminish the systemic acute phase response to infection and modulate the severity of the disease. The IL-1beta binding activity is present in other orthopoxviruses.