Hyperuricemia is an independent competing risk factor for atrial fibrillation
Hyperuricemia is an independent competing risk factor for atrial fibrillation
复制标题
DOI：
10.1016/j.ijcard.2016.11.268
复制
发表时间：
2017-03-15
影响因子：
3.5
通讯作者：
Hisatome, Ichiro
中科院分区：
文献类型：
--
作者：
Kuwabara, Masanari;Niwa, Koichiro;Hisatome, Ichiro
背景资料：血尿酸（SUA）与房颤（AF）之间的关系尚不清楚，因为许多参数和疾病都会影响AF。本研究旨在明确高尿酸血症作为AF独立竞争危险因素在健康人群中的作用。方法：我们回顾性分析了在东京圣卢克国际医院接受年度定期健康检查的90，143名日本受试者的医疗记录，2004年1月至2010年6月。在这些受试者中，291例（0.32%）通过12导联心电图确定为AF。首先，我们分析了90，117例受试者，以阐明AF的独立竞争风险因素，并通过logistic回归分析获得比值比（OR）。结果：（1）房颤组SUA水平显著高于非房颤组（OR：1.35，95%CI：1.22 - 1.50），且房颤组SUA水平显著高于非房颤组（OR：1.35，95%CI：1.22-1.50）。高尿酸血症（SUA> 7.0 mg/dL）对AF的OR为2.75（95% CI，2.10-3.60）。第二，经多次校正后，较高的SUA水平（OR：1.53; 95%CI，1.21-1.92）是AF的显著独立竞争风险因素，以及年龄较大、男性、较高的体重指数、较低的FEV 1/FVC和较高的血红蛋白。结论：高尿酸血症是房颤的独立竞争危险因素，降低血尿酸水平对预防房颤的重要性尚需进一步的前瞻性干预研究。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Backgrounds: The relationship between serumuric acid (SUA) and atrial fibrillation (AF) remains unclear because many parameters and diseases influence AF. This study was conducted to clarify the role of hyperuricemia as an independent competing risk factor for AF in an apparently healthy general population.Methods: We retrospectively analyzed the medical records of 90,143 Japanese subjects who underwent annual regular health check-up in St. Luke's International Hospital, Tokyo, between January 2004 and June 2010. Of those subjects, 291 (0.32%) were identified as having AF by 12 leads electrocardiography. First, we analyzed 90,117 subjects to clarify the independent competing risk factors for AF and obtained odds ratios (ORs) by logistic regression analysis. Second, we excluded 40,825 subjects with hypertension, diabetes mellitus, dyslipidemia, chronic kidney disease, and current medication for hyperuricemia and/or gout, andwe analyzed 49,292 subjects.Results: First, AF groups were significantly higher SUA level (OR: 1.35; 95% confidence interval (CI), 1.22-1.50) than non-AF group. OR of hyperuricemia (> 7.0 mg/dL of SUA) for AF was 2.75 (95% CI, 2.10-3.60). Second, after multiple adjustments, higher SUA level (OR: 1.53; 95% CI, 1.21-1.92) was a significantly independent competing risk factor for AF, as well as older age, male sex, higher body mass index, lower FEV1/FVC, and higher hemoglobin. OR of hyperuricemia for AF was 3.19 (95% CI, 1.81-5.62).Conclusions: Hyperuricemia is an independent competing risk factor for AF. Further prospective intervention studies are needed to prove whether lowering SUA level might be important for preventing AF or not. (C) 2016 Elsevier Ireland Ltd. All rights reserved.