TIMED-RELEASE DEPOT FOR ANTICANCER AGENTS
TIMED-RELEASE DEPOT FOR ANTICANCER AGENTS
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DOI：
10.1002/jps.2600640124
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发表时间：
1975-01-01
影响因子：
3.8
通讯作者：
MEYER, FJ
中科院分区：
文献类型：
--
作者：
YOLLES, S;LEAFE, TD;MEYER, FJ
在大鼠中研究了抗癌剂从具有聚乳酸的复合材料中的定时释放。在环磷酰胺-聚乳酸复合材料的情况下，67%的给药剂量在34天内释放。使用顺式二氯二氨铂（II），在同一时期内的药物释放量仅为9.3%。这种差异可能归因于这两种药物在聚合物中的不同溶解度。电子能谱化学分析是一种新的研究药物在聚合物膜中扩散程度的方法。
The timed‐release of anticancer agents from composites with poly(lactic acid) was studied in rats. In the case of cyclo‐phosphamide–poly(lactic acid) composites, 67% of the administered dose was released within 34 days. Withcisdichlorodiam‐mineplatinum (II), the amount of drug released was only 9.3% within the same period. This difference might be attributed to the different solubilities of these two drugs in the polymer. Electron spectroscopy chemical analysis, a new tool, was used to investigate the extent of diffusion of drugs in polymer films.