Baseline differences between vascular cognitive impairment no dementia reverters and non-reverters.
Baseline differences between vascular cognitive impairment no dementia reverters and non-reverters.
复制标题
血管性认知障碍无痴呆恢复者和非痴呆恢复者之间的基线差异。
DOI：
10.1136/jnnp.2007.137554
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Gorelick,P
中科院分区：
文献类型：
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作者：
Williamson,JB;Nyenhuis,DL;Pedelty,L;Byrd,S;Jhaveri,M;Wang,C;deToledo-Morrell,L;Sripathirathan,K;Gorelick,P
研究背景脑卒中患者认知功能恢复正常的潜在因素尚不清楚。我们比较了血管性认知障碍，无痴呆，方法31名符合血管CIND分类标准的缺血性中风患者年龄>49.5岁，符合NINDS中风标准，并且没有其他神经系统疾病，完成基线和1年检查。45%的血管CIND参与者恢复到没有认知功能障碍，在1年的随访examination.ResultsThere是更大的认知功能障碍，在非回复跨越几个神经心理学领域的总分和精神和工作记忆的总分。回复者和非回复者之间的人口统计学因素或卒中严重程度没有差异。结构性MRI分析显示，卒中次数、卒中量或卒中位置无基线差异。然而，有更大的额叶白色物质高强度负荷在non-reverter group.ConclusionsThese结果表明，血管CIND逆转可能是一个功能的基线神经心理功能和脑血管疾病的位置相结合。
BackgroundThe underlying factors of reversion from cognitive impairment to normal cognitive functioning in stroke are not well understood. We compare demographic, cognitive and imaging factors in Vascular Cognitive Impairment, No Dementia (Vascular CIND) patients who revert to normal cognitive functioning to Vascular CIND patients who do not revert.MethodsThirty-one ischaemic stroke patients, who met classification criteria for Vascular CIND, were >49.5 years old, met NINDS stroke criteria, and were free from additional neurological illness, completed baseline and 1-year examinations. Forty-five per cent of the Vascular CIND participants reverted to no cognitive impairment at 1-year follow-up examination.ResultsThere was greater cognitive impairment in non-reverters on a summary score spanning several neuropsychological domains and on psychomotor and working memory summary scores. There were no differences on demographic factors or in stroke severity between reverters and non-reverters. Structural MRI analyses revealed no baseline differences in number of strokes, stroke volume or stroke location. However, there was greater frontal white matter hyperintensity load in the non-reverter group.ConclusionsThese results suggest that Vascular CIND reversion may be a function of a combination of baseline neuropsychological function and location of cerebrovascular disease.