Differential development of two classes of acetylcholine receptors in Xenopus muscle in culture.
Differential development of two classes of acetylcholine receptors in Xenopus muscle in culture.
复制标题
培养的非洲爪蟾肌肉中两类乙酰胆碱受体的差异发育。
DOI：
10.1126/science.6474189
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Takahashi,T
中科院分区：
文献类型：
--
作者：
Leonard,RJ;Nakajima,S;Nakajima,Y;Takahashi,T
Physiological properties of acetylcholine receptors on muscle cells at very early stages of ontogeny were compared with those of cells at later stages. Two changes were observed that contributed to an overall shortening of the mean open time of single-channels. First, there was a shift in the relative proportions of two receptor types with different conductances and mean open times, such that the contribution of receptors with large conductance and short open time increased as development proceeded. Second, there was a sharp reduction in the mean open time of channels having small conductance, with no similar change in channels having large conductance.
