Epidemiologic correlates of serum folate and homocysteine levels among users and non-users of vitamin supplement.
Epidemiologic correlates of serum folate and homocysteine levels among users and non-users of vitamin supplement.
复制标题
维生素补充剂使用者和非使用者之间血清叶酸和同型半胱氨酸水平的流行病学相关性。
DOI：
10.1024/0300-9831.69.5.322
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Riboli,E
中科院分区：
文献类型：
--
作者：
Kato,I;Dnistrian,AM;Schwartz,M;Toniolo,P;Koenig,K;Shore,RE;Zeleniuch-Jacquotte,A;Akhmedkhanov,A;Riboli,E
Lower serum folate and higher serum homocysteine levels are known risk factors for various conditions. Thus, epidemiologic correlates with these measurements were studied for 256 multivitamin users and 230 non-users who were middle-aged women. Both serum folate and homocysteine levels increased with advancing age in both multivitamin users (P < 0.01 and P < 0.01) and non-users (P = 0.08 and P < 0.01). Among non-users, higher intake of vegetables, fruits, cold cereals and total protein were associated positively with serum folate and inversely with homocysteine levels. There were 25–74% increases in serum folate and 10–15% decreases in serum homocysteine between 1st and 4th quartiles of intake of these food/nutrients. In addition, 26% lower serum folage and 18% higher serum homocysteine were observed for those smoking 20 or more cigarettes per day compared with non-smokers. Among multivitamin users, body weight was correlated inversely with serum folate (P < 0.01) and positively with serum homocysteine levels (P = 0.04), while no correlates were found among lifestyle factors. Regular use of multivitamins increased serum folate about fourfold and decreased homocysteine twofold. These results suggest that multivitamin use can offset the effects of an unhealthy lifestyle on these serum markers, and that levels of serum folate and homocysteine can also be favorably influenced by healthier diet and abstinence from smoking.
