THE EFFECT OF CHRONIC PHENYTOIN-TREATMENT ON SERUM-LIPID PROFILE IN ADULT EPILEPTIC PATIENTS
THE EFFECT OF CHRONIC PHENYTOIN-TREATMENT ON SERUM-LIPID PROFILE IN ADULT EPILEPTIC PATIENTS
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DOI：
10.1111/j.1528-1157.1992.tb02299.x
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发表时间：
1992-01-01
期刊：
影响因子：
5.6
通讯作者：
DELACALZADA, DG
中科院分区：
文献类型：
--
作者：
CALANDRE, EP;PORTA, BS;DELACALZADA, DG
对100例慢性苯妥英钠(PHT)治疗的成年癫痫患者和100例正常对照的血清总胆固醇、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、极低密度脂蛋白胆固醇(VLDL)、载脂蛋白A、载脂蛋白A1、载脂蛋白B和谷氨酰转移酶(GGT)进行了检测。与对照组相比，患者表现出更高的高密度脂蛋白胆固醇、载脂蛋白A和A1以及GGT水平，而低密度脂蛋白胆固醇和载脂蛋白B的值更低；这一结果在女性中的意义比在男性中更大。在患者中，GGT水平与PHT血浆浓度呈正相关；同样，载脂蛋白A/A1比率与PHT、GGT血浆水平呈负相关，而载脂蛋白A/A1比率与低密度脂蛋白/高密度脂蛋白胆固醇比率呈正相关。这些数据表明，PHT对血脂谱有有益的影响。
Total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very-low-density lipoprotein cholesterol, apolipoproteins A, A1, and B and gamma-glutamyltransferase (ggt) serum concentrations were measured in 100 adult epileptic patients receiving chronic phenytoin (PHT) treatment and in 100 control subjects. In relation to controls, patients showed higher HDL cholesterol, apolipoproteins A and A1, and ggt levels and lower LDL cholesterol and apolipoprotein B values; the significance of the results was greater in women than in men. Among patients, ggt levels were positively correlated with PHT plasma concentrations; likewise, a negative correlation was found between the apolipoprotein A/A1 ratio and the PHT and ggt plasma levels, and a positive correlation between the apolipoprotein A/A1 ratio and the LDL/HDL cholesterol ratio. These data indicate that PHT exerts a beneficial effect on the serum lipids profile.