Centers for Disease Control and Prevention Calculating Total Daily Dose of Opioids for Safer Dosage
Centers for Disease Control and Prevention Calculating Total Daily Dose of Opioids for Safer Dosage
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疾病控制和预防中心计算阿片类药物的每日总剂量以获得更安全的剂量
DOI：
10.1891/9780826143129.ap03
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
A. Labbé
中科院分区：
文献类型：
--
作者：
P. Zeboulon;Pierre;E. Brasnu;V. Aragno;P. Hamard;C. Baudouin;A. Labbé
较高剂量的阿片类药物与过量和死亡的风险更高相关--即使相对较低的剂量(每天20-50毫克吗啡当量(MME))也会增加风险。从长远来看，更高的剂量并不能减少疼痛。一项随机试验发现，在更自由的阿片类药物剂量递增策略(平均最终剂量为52 Mme)和维持当前剂量(平均最终剂量为40 Mme)之间，疼痛或功能没有差异。
Higher dosages of opioids are associated with higher risk of overdose and death — even relatively low dosages (20-50 morphine milligram equivalents (MME) per day) increase risk. Higher dosages haven’t been shown to reduce pain over the long term. One randomized trial found no difference in pain or function between a more liberal opioid dose escalation strategy (with average final dosage 52 MME) and maintenance of current dosage (average final dosage 40 MME).