Age-related changes in brain regional activity during chewing: A functional magnetic resonance imaging study
Age-related changes in brain regional activity during chewing: A functional magnetic resonance imaging study
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DOI：
10.1177/154405910308200817
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发表时间：
2003-08-01
影响因子：
7.6
通讯作者：
Saito, S
中科院分区：
文献类型：
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作者：
Onozuka, M;Fujita, M;Saito, S
咀嚼诱导的脑神经元活动的咀嚼相关的变化已经提出。然而，在人类中，对所涉及的解剖区域知之甚少。在有节奏地咀嚼口香糖和不咀嚼口香糖的周期中使用功能磁共振成像，我们研究了年龄对年轻成年人（19-26岁）、中年人（42-55岁）和老年人（65-73岁）健康人咀嚼口香糖时大脑区域活动的影响。在所有受试者中，咀嚼导致感觉运动皮层、小脑、丘脑、辅助运动区和小脑皮层的BOLD信号双侧增加，右侧前额叶区单侧增加。在前三个区域中，信号增加以年龄依赖的方式衰减，而在右前额叶区，则匡威。其余两个区域在年龄上无显著差异。这些结果表明，咀嚼导致大脑中神经元活动的区域增加，其中一些是年龄依赖性的。
Age-related changes in mastication-induced brain neuronal activity have been suggested. However, in humans, little is known about the anatomical regions involved. Using fMRI during cycles of rhythmic gum-chewing and no chewing, we have examined the effect of aging on brain regional activity during chewing in young adult (19-26 yrs), middle-aged (42-55 yrs), and aged (65-73 yrs) healthy humans. In all subjects chewing resulted in a bilateral increase in the BOLD signals in the sensorimotor cortex, cerebellum, thalamus, supplementary motor area and insula, and a unilateral increase in the right prefrontal area. In the first three regions, the signal increases were attenuated in an age-dependent manner, whereas, in the right prefrontal area, the converse was seen. The remaining two regions showed no significant differences with ages. These results indicate that chewing causes regional increases in neuronal activity in the brain, some of which are age-dependent.