PLAC1, an Xq26 gene with placenta-specific expression
PLAC1, an Xq26 gene with placenta-specific expression
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DOI：
10.1006/geno.2000.6302
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发表时间：
2000-09-15
期刊：
影响因子：
4.4
通讯作者：
Schlessinger, D
中科院分区：
文献类型：
--
作者：
Cocchia, M;Huber, R;Schlessinger, D
一个新的人类x连锁基因显示胎盘特异性表达，并已被命名为PLAC1。该基因与HPRT在Xq26位点的端粒图谱为65kb，已在cDNA和基因组水平上完成测序。小鼠同源物Plac1映射到小鼠X染色体的同步等效区域。小鼠胚胎发生过程中反义mRNA的原位杂交研究检测到Plac1在胎盘外晶状体、巨细胞和迷路滋养细胞中从7.5 dpc（交尾后天）到14.5 dpc的表达。假定的人类和小鼠PLAC1蛋白60%相同，77%同源，两者都包含一个信号肽和一个在ZP3（透明带3）蛋白相互作用域中也发现的肽序列。这些结果使PLAC1成为胎盘发育的标记物，可能在母胎界面的建立中起作用。(C) 2000年学术出版社。
A novel human X-linked gene shows placenta-specific expression and has been named PLAC1. The gene maps 65 kb telomeric to HPRT at Xq26 and has been completely sequenced at the cDNA and genomic levels. The mouse orthologue Plac1 maps to the syntenically equivalent region of the mouse X chromosome. In situ hybridization studies with the antisense mRNA during mouse embryogenesis detect Plac1 expression from 7.5 dpc (days postcoitum) to 14.5 dpc in ectoplacental cone, giant cells, and labyrinthine trophoblasts. The putative human and murine PLAC1 proteins are 60% identical and 77% homologous, Both include a signal peptide and a peptide sequence also found in an interaction domain of the ZP3 (zona pellucida 3) protein. These results make PLAC1 a marker for placental development, with a possible role in the establishment of the mother-fetus interface. (C) 2000 Academic Press.