Gestational diabetes mellitus causes changes in the concentrations of adipocyte fatty acid-binding protein and other adipocytokines in cord blood.
Gestational diabetes mellitus causes changes in the concentrations of adipocyte fatty acid-binding protein and other adipocytokines in cord blood.
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DOI：
10.2337/dc11-0715
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发表时间：
2011-09
期刊：
影响因子：
16.2
通讯作者：
Herrera E
中科院分区：
文献类型：
--
作者：
Ortega-Senovilla H;Schaefer-Graf U;Meitzner K;Abou-Dakn M;Graf K;Kintscher U;Herrera E
测定妊娠期糖尿病（GDM）孕妇和对照组孕妇血清和脐带血中脂肪细胞脂肪酸结合蛋白（AFABP）和其他脂肪细胞因子的浓度，并将其与胰岛素敏感性指标相关联。对照组86例，GDM组98例，阴道分娩前采静脉血，分娩后立即采脐带血。采用酶联免疫吸附试验（ELISA）测定血清胰岛素和脂肪细胞因子。GDM组孕妇孕前BMI较高，数据经校正后，GDM组孕妇血清胰岛素、胰岛素/葡萄糖比值、稳态模型评估（HOMA）、AFABP和视黄醇结合蛋白4（RBP 4）高于对照组，脂联素低于对照组，而血糖、胰岛素、胰岛素/葡萄糖比值、HOMA、非酯化脂肪酸和RBP 4高于对照组，甘油、AFABP、GDM组脐血血清脂联素水平低于对照组。对照组脐带血中AFABP和脂联素水平均高于母体血清; GDM组脐带血中AFABP水平与母体血清无差异，但脐带血中脂联素水平仍高于母体血清。两组脐血瘦素水平均低于母血，且仅GDM组RBP 4水平低于母血。提示胎儿组织是脐动脉血清AFABP的主要来源，GDM胎儿AFABP值与肥胖标志物相关。GDM母亲及其胎儿的脂联素下调和RBP 4上调可能与其胰岛素抵抗状况有关，而AFABP的变化似乎无关。
To determine the concentrations of adipocyte fatty acid–binding protein (AFABP) and other adipocytokines in maternal and cord serum of pregnant women with gestational diabetes mellitus (GDM) and of control subjects and to relate them to indexes of insulin sensitivity. In 86 control and 98 GDM pregnant women, venous blood was collected before vaginal delivery and arterial blood from cord immediately after delivery. Serum insulin and adipocytokines were measured by enzyme-linked immunosorbent assay (ELISA). GDM women had higher prepregnancy BMI, and data were adjusted for it. Maternal serum insulin, insulin-to-glucose ratio, homeostasis model assessment (HOMA), AFABP, and retinol-binding protein 4 (RBP4) were higher and adiponectin was lower in GDM than in control subjects, whereas serum glucose, insulin, insulin-to-glucose ratio, HOMA, nonesterified fatty acids, and RBP4 were higher and glycerol, AFABP, and adiponectin were lower in cord blood serum of GDM than of control subjects. AFABP and adiponectin in cord serum of control subjects were higher than in maternal serum; in GDM women no difference was found for AFABP in cord versus maternal serum, although adiponectin remained higher in cord. Values of leptin in both groups were lower in cord than in maternal serum, and those of RBP4 were lower in only GDM women. It is suggested that fetal tissues are the main source of cord arterial serum AFABP, and in GDM fetuses AFABP values correlate with adiposity markers. A downregulation of adiponectin and upregulation of RBP4 in GDM mothers and their fetuses may be related to their insulin-resistant condition, whereas changes in AFABP do not seem to be related.