Inputs from paraventricular nucleus of thalamus and locus coeruleus contribute to the activation of central nucleus of amygdala during context-induced retrieval of morphine withdrawal memory
Inputs from paraventricular nucleus of thalamus and locus coeruleus contribute to the activation of central nucleus of amygdala during context-induced retrieval of morphine withdrawal memory
复制标题
丘脑室旁核和蓝斑的输入有助于在情境诱导的吗啡戒断记忆检索过程中激活杏仁核中央核
DOI：
10.1016/j.expneurol.2021.113600
复制
发表时间：
2021
影响因子：
5.3
通讯作者：
P. Zheng
中科院分区：
文献类型：
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作者：
Yingqi Wang;Yan Pan;Zhangying Cai;Chao Lei;Xinli Guo;Dongyang Cui;Yu Yuan;B. Lai;P. Zheng
复吸主要归因于条件情境诱发的戒断记忆的恢复。以往的研究表明，杏仁核外侧区中央核（CeL）可被条件性语境激活。然而，什么样的输入源，激活细胞在条件情境诱导提取吗啡戒断记忆仍然是未知的。本研究利用逆行标记、免疫组织化学、局部显微注射和化学遗传学技术发现：（1）条件情境诱导CeL激活，而CeL的抑制则抑制了情境诱导的吗啡戒断记忆的提取;（2）抑制丘脑室旁核（PVT）或PVT-条件性语境和条件性位置厌恶（CPA）可减弱CeL投射神经元的激活;（3）抑制蓝斑（LC）或LC-CeL投射神经元可降低条件性情境和CPA对CeL的激活。这些结果表明，CeL是必要的条件性上下文诱导的吗啡戒断记忆的提取和输入从PVT和LC有助于激活CeL在上下文诱导的吗啡戒断记忆的提取。
Drug relapse can be mainly ascribed to the retrieval of drug withdrawal memory induced by conditioned context. Previous studies have shown that the central nucleus of the amygdala lateral division (CeL) could be activated by conditioned context. However, what source of input that activates the CeL during conditioned context-induced retrieval of morphine-withdrawal memory remains unknown. In this study, using retrograde labeling, immunohistochemistry, local microinjection and chemogenetic technologies, we found that (1) Conditioned context induced an activation of the CeL and the inhibition of the CeL inhibited the context-induced retrieval of morphine-withdrawal memory; (2) the inhibition of the paraventricular nucleus of thalamus (PVT) or PVT-CeL projection neurons caused an attenuation of the activation of the CeL by conditioned context and conditioned place aversion (CPA); (3) the inhibition of the locus coeruleus (LC) or LC-CeL projection neurons decreased the activation of the CeL by conditioned context and CPA. These results suggest that the CeL is necessary for conditioned context-induced retrieval of morphine-withdrawal memory and inputs from PVT and LC contribute to the activation of the CeL during context-induced retrieval of morphine withdrawal memory.
投射到前额皮质的蓝斑去甲肾上腺素能神经元亚群在意外逆转期间调节灵活的记忆过程。
DOI：
--
发表时间：
2023
期刊：
影响因子：
--
作者：
Amemiya S;McHugh T
通讯作者：
McHugh T