US Epidemiology of Breast Implant-Associated Anaplastic Large Cell Lymphoma
US Epidemiology of Breast Implant-Associated Anaplastic Large Cell Lymphoma
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DOI：
10.1097/prs.0000000000003282
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发表时间：
2017-05-01
影响因子：
3.6
通讯作者：
Clemens, Mark W.
中科院分区：
文献类型：
--
作者：
Doren, Erin L.;Miranda, Roberto N.;Clemens, Mark W.
背景资料：乳房植入体相关间变性大细胞淋巴瘤（ALCL）是一种发生在乳房植入体周围的独特类型的T细胞淋巴瘤。尽管罕见，但所有具有足够病史的病例均涉及毛面乳房植入体。本研究的目的是确定美国乳房植入体相关ALCL的发病率和终身患病率在美国的妇女与毛面乳房implants.Methods：这是一个回顾性审查的记录案件的乳房植入体相关ALCL在美国从1996年至2015年。的发病率和患病率的基础上确定的文献和机构数据库审查乳房植入体相关的ALCL案件和纹理乳房植入体的销售数字从植入体制造商的年度data.Results：一百病理证实的乳房植入体相关的ALCL案件在美国。诊断时的平均年龄为53.2 ± 12.3岁。从种植体植入到诊断的平均间隔时间为10.7 ± 4.6年。49名患者因美容原因植入乳房植入体，44名患者因乳房切除术重建，7名患者因不明原因植入乳房植入体。假设乳房植入体相关ALCL仅发生在毛面乳房植入体中，其发生率为2.03/100万人-年（203/1亿人-年），是一般人群中乳房原发性ALCL发生率的67.6倍（3/1亿人-年; p < 0.001）。终身患病率为33每100万人与毛面乳房implants.Conclusions：这项研究表明，毛面乳房植入体和乳房植入体相关ALCL之间的统计学显着关联。尽管植入毛面乳房植入体的女性发生乳房植入体相关ALCL的风险较低，但目前美国的发病率显著高于一般人群中乳房原发性ALCL的发病率。
Background: Breast implant-associated anaplastic large cell lymphoma (ALCL) is a distinctive type of T-cell lymphoma that arises around breast implants. Although rare, all cases with adequate history have involved a textured breast implant. The objective of this study was to determine the U.S. incidence and lifetime prevalence of breast implant-associated ALCL in women with textured breast implants.Methods: This is a retrospective review of documented cases of breast implant-associated ALCL in the United States from 1996 to 2015. The incidence and prevalence were determined based on a literature and institutional database review of breast implant-associated ALCL cases and textured breast implant sales figures from implant manufacturers' annualized data.Results: One hundred pathologically confirmed breast implant-associated ALCL cases were identified in the United States. Mean age at diagnosis was 53.2 +/- 12.3 years. Mean interval from implant placement to diagnosis was 10.7 +/- 4.6 years. Forty-nine patients had breast implants placed for cosmetic reasons, 44 for mastectomy reconstruction, and seven for unknown reasons. Assuming that breast implant-associated ALCL occurs only in textured breast implants, the incidence rate is 2.03 per 1 million person-years (203 per 100 million person-years), which is 67.6 times higher than that of primary ALCL of the breast in the general population (three per 100 million per year; p < 0.001). Lifetime prevalence was 33 per 1 million persons with textured breast implants.Conclusions: This study demonstrates a statistically significant association between textured breast implants and breast implant-associated ALCL. Although women with a textured breast implant have a low risk of developing breast implant-associated ALCL, the current U.S. incidence is significantly higher than that of primary ALCL of the breast in the general population.