Neurotrophic electrode: Method of assembly and implantation into human motor speech cortex
Neurotrophic electrode: Method of assembly and implantation into human motor speech cortex
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DOI：
10.1016/j.jneumeth.2008.06.030
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发表时间：
2008-09-30
影响因子：
3
通讯作者：
Kennedy, Philip
中科院分区：
文献类型：
--
作者：
Bartels, Jess;Andreasen, Dinal;Kennedy, Philip
神经营养电极(NE)是为延长记录信号的寿命和稳定性而设计的。为了达到这一目的，它诱导神经突起通过其玻璃尖端生长，从而将其锚定在神经纤维中。玻璃尖端包含绝缘的金丝，用于记录生长到尖端的有髓神经突起的活动。尖端内的神经信号通过玻璃与周围的神经活动电绝缘。最新版本的电极在其尖端有四根导线，以最大限度地增加从内生神经突起记录的可识别信号的数量，并有一个微型连接器。柔性缠绕的绝缘金线连接到头骨上的电子设备，这些电子设备仍然留在皮下。植入的电子设备由差动放大器、调频发射机和加电时的正弦波组成，用于调谐和校准。选择锁定对象的纳入标准包括医疗稳定性、正常认知和强有力的照顾者支持。植入靶点通过功能磁共振命名任务进行定位。手术中的最终定位是通过三维立体定位实现的。在录音过程中，植入的电子设备由气隙中的磁感应供电。放置在头皮上的螺旋天线覆盖在植入的发射机上，接收放大的FM发射机输出。数据按照其他地方的描述进行处理，其中解决了稳定性和寿命问题。已有5名受试者成功植入NE。在两名死于潜在疾病的受试者中，记录的信号持续了4年以上，而在我们目前的受试者中，记录的信号持续了3年以上。(C)2008爱思唯尔B.V.保留所有权利。
The neurotrophic electrode (NE) is designed for longevity and stability of recorded signals. To achieve this aim it induces neurites to grow through its glass tip, thus anchoring it in neuropil. The glass tip contains insulated gold wires for recording the activity of the myelinated neurites that grow into the tip. Neural signals inside the tip are electrically insulated from surrounding neural activity by the glass. The most recent version of the electrode has four wires inside its tip to maximize the number of discriminable signals recorded from ingrown neurites, and has a miniature connector. Flexible coiled, insulated gold wires connect to electronics on the skull that remain subcutaneous. The implanted electronics consist of differential amplifiers, FM transmitters, and a sine wave at power up for tuning and calibration. Inclusion criteria for selecting locked-in subjects include medical stability, normal cognition, and strong caregiver support. The implant target is localized via an fMRI-naming task. Final localization at surgery is achieved by 3D stereotaxic localization. During recording, implanted electronics are powered by magnetic induction across an air gap. Coiled antennas placed on the scalp over the implanted transmitters receive the amplified FM transmitter outputs. Data is processed as described elsewhere where stability and longevity issues are addressed. Five subjects have been successfully implanted with the NE. Recorded signals persisted for over 4 years in two subjects who died from underlying illnesses, and continue for over 3 years in our present subject. (C) 2008 Elsevier B.V. All rights reserved.