Biochemical markers of bone turnover in Camurati-Engelmann disease: A report on four cases in one family
Biochemical markers of bone turnover in Camurati-Engelmann disease: A report on four cases in one family
复制标题
DOI：
10.1007/s002239900293
复制
发表时间：
1997-07-01
影响因子：
4.2
通讯作者：
MunozGomez, J
中科院分区：
文献类型：
--
作者：
Hernandez, MV;Peris, P;MunozGomez, J
仅在一些Camurati-Engelmann病患者中描述了骨转换“经典”生化标志物的适度增加。然而，以下“新”标记物的测定此前尚未进行：血清骨钙素（BGP）、骨碱性磷酸酶（BAP）、I型前胶原羧基末端前肽（PICP）、I型前胶原氨基末端前肽（PINP）、抗酒石酸酸性磷酸酶（TRAP）、I型胶原末端肽羧基末端（ICTP）、尿吡啶啉（PYR）、I型胶原交联n -末端肽（NTX）和Crosslaps （CL）。这样的测定可以改进对疾病活动性的评价。为了评估反映Camurati-Engelmann病活动性的骨转换生化标志物的有效性，我们测量了4名受影响患者的所有这些标志物的水平。结果与疾病活动性骨显像指标进行比较。除PICP和TRAP外，所有患者骨形成和骨吸收标志物均异常，且与疾病活动性骨扫描指标相关。骨形成标志物中PINP、BAP和BGP值最高，而NTX和CL是骨吸收最敏感的标志物。这些结果表明，与骨扫描评估相关的NTX或CL， PINP或BAP和BGP的测定，提供了对Camurati-Engelmann病活动性的最佳评估。
Moderate increases in ''classical'' biochemical markers of bone turnover have been described only in some patients with Camurati-Engelmann disease. However, the determination of the following ''new'' markers has not been previously performed: serum osteocalcin (BGP), bone alkaline phosphatase (BAP), carboxyterminal propeptide of type I procollagen (PICP), aminoterminal propeptide of type I procollagen (PINP), tartrate-resistant acid phosphatase (TRAP), telopeptide carboxyterminal of type I collagen (ICTP), urinary pyridinoline (PYR), crosslinked N-telopeptides of type I collagen (NTX), and Crosslaps (CL). Such a determination may improve the evaluation of the disease activity. To evaluate the usefulness of biochemical markers of bone turnover reflecting Camurati-Engelmann disease activity we measured the levels of all these markers in four affected patients. The results were compared with bone scintigraphic indices of disease activity. Except for PICP and TRAP, bone formation and resorption markers were abnormal in all patients and were related to bone scan indices of disease activity. Among the markers of bone formation PINP, BAP, and BGP showed the highest values, whereas NTX and CL were the most sensitive markers of bone resorption. These results suggest that the determination of NTX or CL, and PINP or either BAP and BGP, associated with bone scan evaluation, provides the best assessment of Camurati-Engelmann disease activity.