Neurobiological factors in personality and depression
Neurobiological factors in personality and depression
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DOI：
10.1002/per.2410090509
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发表时间：
1995-12-01
影响因子：
5.9
通讯作者：
Depue, RA
中科院分区：
文献类型：
--
作者：
Depue, RA
直接评估人格超级因素与抑郁倾向之间的神经生物学关联的实证研究非常少。因此，作为为未来研究提供框架的一种手段，本文概述了三种主要人格超因素的假定神经生物学基础：积极情绪或外向性、约束或精神病性、以及消极情绪或神经质。这些超级因子的神经生物学，尤其是中枢多巴胺、血清素和去甲肾上腺素投射系统，主要来源于动物生物行为研究，尽管在可能的情况下也讨论了人类工作。为了探索该框架与抑郁症的关联，我们从不同形式的抑郁症以及抑郁症表型和病程的改变的角度讨论了由此产生的神经生物系统的极端数量变化，无论是单独的还是彼此相互作用的。经验对神经生物学功能的影响被简单地认为是一种治疗方法，代替行为的药理学调节或与之相互作用。
There is very little empirical work that directly assesses the neurobiological association of personality superfactors with the liability to depression. Therefore, as a means of providing a framework for future research, this article outlines the putative neurobiological foundation of three major personality superfactors: positive emotionality or extraversion, constraint or psychoticism, and negative emotionality or neuroticism. The neurobiology of these superfactors, particularly the central dopamine, serotonin, and norepinephrine projection systems, respectively, is derived largely from animal biobehavioral research, although human work is discussed where available. In an attempt to explore the association of this framework to depression, extreme quantitative variation in the resulting neurobiological systems, alone and in interaction with each other, is discussed in terms of different forms of depression and of modification of the phenotype and course of depression. The effects of experience on neurobiological functioning is briefly considered as a therapeutic approach, in lieu of, or in interaction with, pharmacological modulation of behavior.