The negative cell cycle regulator, Tob (transducer of ErbB-2), is a multifunctional protein involved in hippocampus-dependent learning and memory
The negative cell cycle regulator, Tob (transducer of ErbB-2), is a multifunctional protein involved in hippocampus-dependent learning and memory
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DOI：
10.1016/j.neuroscience.2004.10.044
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发表时间：
2005-01-01
期刊：
影响因子：
3.3
通讯作者：
Yu, L
中科院分区：
文献类型：
--
作者：
Jin, M;Wang, XM;Yu, L
Tob（ErbB2的转换器）是一种在外周具有抗增殖活性的负性细胞周期调节剂。使用行为筛选范式来寻找大脑中的新基因功能，我们将Tob鉴定为参与学习和记忆的脑表达蛋白。恐惧调节的行为训练引发了Tob蛋白的短暂升高，这先于长期记忆的形成。在大鼠中通过CA1内输注反义寡核苷酸对Tob的功能干扰损害了Morris水迷宫中的空间学习和记忆以及上下文恐惧条件反射的长期记忆，这两种行为范式需要海马。此外，长时程增强抑制Tob反义输注到CA 1区。总之，这些结果表明，负细胞周期调节Tob是一个多功能的蛋白质参与海马依赖性学习和记忆。(c)2005年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Tob (transducer of ErbB2) is a negative cell cycle regulator with anti-proliferative activity in the periphery. Using a behavioral screening paradigm to look for novel gene functions in the brain, we identified Tob as a brain-expressed protein involved in learning and memory. Behavioral training of fear-conditioning triggered a transient elevation of Tob protein, which preceded the formation of long-term memory. Functional perturbation of Tob by intra-CA1 infusion of antisense oligonucleotides in rats impaired spatial learning and memory in the Morris water maze and long-term memory for contextual fear conditioning, two behavioral paradigms that require the hippocampus. Furthermore, long-term potentiation was suppressed by Tob antisense infusion into the CA1 region. Together, these results indicate that the negative cell cycle regulator Tob is a multifunctional protein involved in hippocampus-dependent learning and memory. (c) 2005 IBRO. Published by Elsevier Ltd. All rights reserved.