Emerging Infectious Diseases
Emerging Infectious Diseases
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DOI：
10.4135/9781452240077.n15
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
G. Steelfisher;R. Blendon;John M. Benson;Kathleen J. Weldon
中科院分区：
文献类型：
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作者：
G. Steelfisher;R. Blendon;John M. Benson;Kathleen J. Weldon
也许没有哪个研究领域比微生物学领域更能被基因组技术的应用所激发。5年前，基因组研究所发表了第一份自由生物体流感嗜血杆菌的完整基因组序列(1)。从那时起，又发表了27个微生物基因组序列（2-28）和3个低等真核生物染色体序列（29-31），并且至少有三倍于此的测序项目正在进行中。一些重要的人类病原体包括：幽门螺杆菌（7,19）、伯氏疏螺旋体（12）、梅毒螺旋体（16）、结核分枝杆菌（15）、普鲁泽氏立克次体（18）和衣原体（17,20）；已知最简单的自由生物，生殖支原体（Mycoplasma genitalium）；模式生物，大肠杆菌(8)和枯草芽孢杆菌（10）；aeolicus（13）和Thermotoga maritima(21)，这两种嗜热细菌可能代表了细菌谱系中最深的分支成员；古细菌领域的5个代表（3、9、11、14、28）；以及第一个真核生物酿酒酵母（sacaromyces cerevisiae）。
Perhaps no other field of research has been more energized by the application of genomic technology than the field of microbiology. Five years ago, The Institute for Genomic Research published the first complete genome sequence for a free-living organism, Haemophilus influenzae (1). Since then, 27 more microbial genome sequences (2-28) and 3 lower eukaryotic chromosome sequences (29-31) have been published, and at least three times that many sequencing projects are under way. Several important human pathogens are included: Helicobacter pylori (7,19), Borrelia burgdorferi (12), Treponema pallidum (16), Mycobacterium tuberculosis (15), Rickettsia prowazekii (18), and Chlamydia species (17,20); the simplest known free-living organism, Mycoplasma genitalium (2); the model organisms, Escherichia coli (8) and Bacillus subtilis (10); Aquifex aeolicus (13) and Thermotoga maritima (21), two thermophilic bacterial species that may represent some of the deepest branching members of the bacterial lineage; five representatives of the archaeal domain (3,9,11, 14,28); and the first eukaryote, Saccaromyces cerevisiae (6).