Carquinostatin B, a new neuronal cell-protecting substance produced by Streptomyces exfoliatus.
Carquinostatin B, a new neuronal cell-protecting substance produced by Streptomyces exfoliatus.
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DOI：
10.1271/bbb.61.1768
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发表时间：
1997-10
期刊：
影响因子：
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通讯作者：
Kazuo Shin-ya;T. Kunigami;Jun-Sik Kim;K. Furihata;Yoichi Hayakawa;Haruo Seto
中科院分区：
文献类型：
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作者：
Kazuo Shin-ya;T. Kunigami;Jun-Sik Kim;K. Furihata;Yoichi Hayakawa;Haruo Seto
脑缺血损伤是由L-谷氨酸的兴奋毒性引起的。卡奎司他丁B是从剥离链霉菌2419-SVT 2中分离得到的一种有效的神经保护物质，可保护神经元杂交瘤N18-RE-105细胞免受L-谷氨酸毒性。卡奎司他汀B的结构主要通过NMR研究确定为具有邻醌官能团的咔唑衍生物。
Brain ischemia injury is elicited by the excitotoxicity of L-glutamate. Carquinostatin B was isolated from Streptomyces exfoliatus 2419-SVT2 as a potent neuroprotective substance which protests neuronal hybridoma N18-RE-105 cells from L-glutamate toxicity. The structure of carquinostatin B was established principally by NMR studies to be a carbazole derivative with an ortho quinone function.