Cationic tetrapyrrolic macromolecules as new acetylcholinesterase inhibitors
Cationic tetrapyrrolic macromolecules as new acetylcholinesterase inhibitors
复制标题
DOI：
10.1142/s1088424609001169
复制
发表时间：
2009-08
影响因子：
1.5
通讯作者：
Tian Tian-Tian;Liwei Weng;Shaoru Wang;X. Weng;Li-xia Zhang;Xiang Zhou
中科院分区：
文献类型：
--
作者：
Tian Tian-Tian;Liwei Weng;Shaoru Wang;X. Weng;Li-xia Zhang;Xiang Zhou
一系列四吡咯大环化合物如卟啉、酞菁、咯啉等对乙酰胆碱酯酶（AChE）具有抑制作用。研究了它们的构效关系。其中有几个化合物具有较好的抑制活性，有望成为乙酰胆碱酯酶（AchE）抑制剂的候选化合物。
A series of tetrapyrrolic macrocycles such as porphyrins, phthalocyanines and corroles were found to have inhibitory abilities toward acetylcholinesterase (AChE). Their structure-activity relationship was studied. Several compounds were found to have good inhibitory abilities, which could be developed as potential candidates of acetylcholinesterase (AchE) inhibitors.