Prior gold therapy does not influence the adverse effects of D-penicillamine in rheumatoid arthritis.
Prior gold therapy does not influence the adverse effects of D-penicillamine in rheumatoid arthritis.
复制标题
先前的金疗法不会影响 D-青霉胺对类风湿性关节炎的不良反应。
DOI：
10.1002/art.1780250802
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发表时间：
1982
影响因子：
--
通讯作者：
W. Buchanan
中科院分区：
文献类型：
--
作者：
W. Kean;Colin J. L. Lock;H. Howard;W. Buchanan
自1976年1月至1981年4月，对114例明确或典型类风湿关节炎患者进行前瞻性随访，观察其对D-青霉胺的毒性反应。描述了以前的金硫代马酸钠治疗对D-青霉胺毒性模式的影响。接受D-青霉胺治疗的患者在不良反应方面的总体结果没有显著差异，无论他们既往有金中毒史，既往金疗法但无毒性，还是既往无金疗法。与那些没有发生D-青霉胺中毒的人相比，那些没有发生D-青霉胺中毒的人从黄金中毒到开始接受D-青霉胺治疗的时间更长。这一差异刚刚达到了统计学意义。所接受的总金盐对D-青霉胺治疗的最终结果没有影响，既往接受过金治疗的患者的毒性模式与从未接受过金治疗的患者相似。
One hundred fourteen patients with definite or classic rheumatoid arthritis were followed prospectively between January 1976 and April 1981 to monitor their toxicity pattern to D-penicillamine. The influence of previous sodium aurothiomalate therapy on the toxicity pattern of D-penicillamine is described. There was no significant difference in overall outcome of the patients treated with D-penicillamine with respect to adverse effects, whether they had previous gold toxicity, previous gold therapy but no toxicity, or no previous gold therapy. The time from gold toxicity to the start of D-penicillamine therapy was greater in those who did not develop D-penicillamine toxicity compared with those who did. This difference just reached statistical significance. Total gold salt received had no effect on eventual outcome of D-penicillamine treatment, and the toxicity pattern of D-penicillamine in those patients who had previous gold therapy was similar to those patients who had never received gold therapy.