Retrospective time-trend study of polybrominated diphenyl ether and polybrominated and polychlorinated biphenyl levels in human serum from the United States
Retrospective time-trend study of polybrominated diphenyl ether and polybrominated and polychlorinated biphenyl levels in human serum from the United States
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DOI：
10.1289/ehp.6826
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发表时间：
2004-05-01
影响因子：
10.4
通讯作者：
Patterson, DG
中科院分区：
文献类型：
--
作者：
Sjödin, A;Jones, RS;Patterson, DG
1985年至2002年期间，在美国东南部和1999年至2002年期间在华盛顿西雅图收集的40份人类血清样本中，分别测定了六种多溴联苯醚（PBDEs）、一种六溴联苯（PBB）和一种六氯联苯（PCB）。多溴二苯醚在商业上被用作普通家庭和商业用途中的阻燃剂，其大多数浓度与样本采集时间呈显著正相关，表明在美国采集的血清中这些化合物的浓度正在增加。相比之下，多氯联苯和多溴联苯水平与样本采集年份呈负相关，表明这些化合物的水平自1970年逐步淘汰以来一直在下降。
Six polybrominated diphenyl ethers (PBDEs), one hexabromobiphenyl [polybrominated biphenyl (PBB)], and one hexachlorobiphenyl [polychlorinated biphenyl (PCB)] were measured in 40 human serum pools collected in the southeastern United States during 1985 through 2002 and in Seattle, Washington, for 1999 through 2002. The concentrations of most of the PBDEs, which are commercially used as flame retardants in common household and commercial applications, had significant positive correlations with time of sample collection, showing that the concentrations of these compounds are increasing in serum collected in the United States. In contrast, PCB and PBB levels were negatively correlated with sample collection year, indicating that the levels of these compounds have been decreasing since their phaseout in the 1970.