Subjective and discriminative stimulus effects of two de-nicotinized cigarettes with different tar yields.
Subjective and discriminative stimulus effects of two de-nicotinized cigarettes with different tar yields.
复制标题
两种不同焦油量的脱烟碱卷烟的主观和辨别刺激效应。
DOI：
10.1080/14622200020032123
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Schuh,KJ
中科院分区：
文献类型：
--
作者：
Schuh,LM;Stamat,HM;Downey,KK;Schuh,KJ
研究了卷烟焦油量在主观和辨别刺激效应中的作用。目前吸烟者（n =18）吸两种非尼古丁香烟的FTC产量为0.06毫克尼古丁和12.4毫克（低焦油）或17.9毫克焦油（高焦油）。在30分钟内完成生理测量和视觉模拟量表。随机确定给药顺序并进行平衡。在对两种香烟取样后，志愿者们抽了第三种，即测试香烟。一半的志愿者收到低焦油香烟和一半的高焦油香烟。志愿者识别测试香烟（即，A或B）在第一次抽吸后5、30、60、300和900秒。18名参与者中有8名在4/5的试验中正确识别了测试香烟。视觉模拟量表评分无显着变化，被发现之间的非歧视。然而，在鉴别剂中，低焦油香烟产生了相对于高焦油香烟的显著的正效应，包括良好的药效和刺激。相对于低焦油卷烟，高焦油卷烟产生的负面影响包括粗糙感、沉重感和香味强度。这些参与者通常吸烟的平均焦油量为9.75毫克，低于这里使用的低焦油香烟，可能是他们更喜欢低焦油香烟的原因。没有观察到血压或心率的变化，两种香烟产生相似的一氧化碳增加，表明吸烟时的吸入深度相似。结果表明，香烟焦油产量可能在吸烟偏好中发挥作用。需要进一步的研究来验证在与尼古丁传递的联系消失后偏好是否仍能保持。
The role of tar yield in the subjective and discriminative stimulus effects of cigarette smoking was examined. Current smokers (n =18) smoked two non-nicotine cigarettes with FTC yields of 0.06 mg nicotine and 12.4 mg (low tar) or 17.9 mg tar (high tar). Physiological measures and visual analog scales were completed over a 30-min period. Dosing order was determined randomly and counterbalanced. After sampling both cigarettes, volunteers smoked a third, test cigarette. Half of the volunteers received the low-tar cigarette and half the high-tar cigarette. Volunteers identified the test cigarette (i.e., A or B) at 5, 30, 60, 300, and 900 s after the first puff. Eight of the eighteen participants correctly identified the test cigarette on 4/5 of trials. No significant changes in visual analog scale scores were found among the non-discriminators. However, among discriminators, the low-tar cigarette produced significant positive effects including good drug effects and stimulation relative to the high-tar cigarette. Relative to the low-tar cigarette, the high-tar cigarette produced negative effects including harshness, heaviness, and intensity of flavor. Average tar yield of these participants' usual cigarettes was 9.75 mg, lower than that of the low-tar cigarette used here, possibly accounting for their greater liking of the low-tar cigarette. No changes in blood pressure or heart rate were observed and both cigarettes produced similar carbon monoxide increases, indicating similar depth of inhalation when smoking each. Results suggest cigarette tar yields may play a role in cigarette smoking preferences. Further research is needed to verify whether preferences are maintained after associations with nicotine delivery are extinguished.