Atypical language representation in patients with chronic seizure disorder and achievement deficits with magnetoencephalography
Atypical language representation in patients with chronic seizure disorder and achievement deficits with magnetoencephalography
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DOI：
10.1111/j.0013-9580.2005.48904.x
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发表时间：
2005-04-01
期刊：
影响因子：
5.6
通讯作者：
Papanicolaou, AC
中科院分区：
文献类型：
--
作者：
Breier, JI;Castillo, EM;Papanicolaou, AC
目的：描述语言特异性脑活动和阅读/拼写成绩半球不对称之间的关系，通过使用脑磁图（MEG）：患者（n = 83）与医学难治性复杂部分性发作的左或右半球的起源被归类为有阅读和/或拼写缺陷（RS）或作为不受损（NI）通过使用标准的成绩测试。所有患者都经历了非侵入性功能映射的接受语言皮层使用MEG作为术前癫痫发作手术evaluation.Results的一部分：RS患者左半球癫痫发作发作表现出相对较大的激活和早期发病的晚期，语言特异性MEG活动在右后颞叶和顶叶下区相比，左半球比NI患者。这些发现在个体基础上也是明显的，并且独立于整体智力能力。左半球复杂部分性癫痫患者的阅读和拼写成绩缺陷与非典型语言组织有关，可能是次要的语言功能重组到右-在支持阅读和拼写功能方面不如左半球中的同伦区域有效的半球区域。
Purpose: To characterize the relation between hemispheric asymmetries in language-specific brain activity and reading/spelling achievement by using magnetoencephalography (MEG).Methods: Patients (n = 83) with medically intractable complex partial seizures of either left- or right-hemisphere origin were classified as having reading and/or spelling deficits (RS) or as not impaired (NI) by using standard achievement tests. All patients had undergone noninvasive functional mapping of receptive language cortex by using MEG as part of a preoperative seizure surgery evaluation.Results: RS patients with left-hemisphere seizure onset exhibited relatively greater activation and earlier onset of late, language-specific MEG activity in posterior temporal and inferior parietal areas of the right as compared with the left hemisphere than did NI patients. These findings also were evident on an individual basis and were independent of global intellectual abilities.Conclusions: Reading and spelling achievement deficits in patients with complex partial seizures of left-hemisphere origin are associated with atypical language organization, possibly secondary to reorganization of language function to right-hemisphere areas that are not as efficient as homotopic areas in the left hemisphere in supporting reading and spelling functions.